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However, much of the research done to elucidate the pathophysiology of metabolic dysfuntion uses the classical approach of studying organs obviously implicated in energy metabolism: the pancreas, liver, adipose tissue, kidneys, muscle, brain, and gastrointestinal tract. There is compelling evidence implicating bone-derived factors in energy homeostasis, which tempts us to bring bone to the frontline as a salient predictor of metabolic conditions such as diabetes and osteoporosis. When Looking at the importance of skeletal integrity through the lens of evolution, we find that bone served a survival function. Humans had to consistently be mobile to look for food and shelter. Furthering this logic reveals that bone and energy metabolism are entwined. Therefore, this project aims to 1. identify bone factors that are associated with metabolic conditions and 2. to bridge our knowledge of the skeletal system represented by its cell types and our understanding of energy metabolism of the organism into one integrated subject. 1) Lee, Na Kyung et al. Cell. vol. 130,3 (2007): 456-69. 2) Mosialou, Ioanna et al. Nature vol. 543,7645 (2017): 385-390. 3) Lee, Nicola J et al. Mol Metab vol. 4,3 (2015)164-74.   Fig.1 Research outline framework --> Related Posts PAGE TOP Frontier Research Institute for Interdisciplinary Sciences About FRIS GreetingsOverviewMissionsOrganizationTenure track system in FRISMaps & DirectionsPublicationAnnual MeetingConsultation Desk Researcher Advanced Interdisciplinary Research DivisionCreative Interdisciplinary Research DivisionManaging & Planning DivisionEndowed Research DivisionsSenior-advisorVisiting Professors / Collaborative ResearchersSpecially-appointedOne-time members Feature TopicsFRIS InterviewsFRIS Hub Meeting Research Programs Open Research ProposalResearch Projects Recruit Open Staff PositionsHandbook for International Researchers FRIS CoRE FRIS CoRE FRIS Fund FRIS Fund for Early-Career Independent Researchers External Links for Early Career Researcher Support Division for Interdisciplinary Advanced Research and Education (DIARE) Ensemble Project for Early Career Researchers Support Program for the Article Processing Charge webmail LINK Copyrights © Frontier Research Institute for Interdisciplinary Sciences, Tohoku University All rights reserved. no cache