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Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Themes Researchers JP Top Medical Yeast models of familial Alzheimer disease to screen for gamma-secretase inhibitors and modulators Yeast models of familial Alzheimer disease to screen for gamma-secretase inhibitors and modulators JAPANESEINQUIRY update：2024/01/23     NEXT PREV Features and Uniqueness Using the yeast transcriptional activator Gal4 system, we reconstituted the production of amyloid beta (Aβ), responsible for Alzheimer disease. Aβ production could be monitored by the positive growth in the selection media or by the reporter enzyme (β-Gal). Utilizing familial Alzheimer disease mutants, we established a system to screen for mutations and chemicals that modulate gamma secretase activity and reduce toxic Aβ42. Practical Application Our yeast system can be used to screen for chemicals, natural products, food ingredients, genes, and mutations that modulate γ-secretase activity and block Aβ42 production specifically. We hope to conduct collaboration research with a willing company for a practical application of this technology in industry. Keywords Alzheimer disease amyloid beta gamma-secretase yeast Saccharomyces cerevisiae gamma-secretase modulator medicine Researchers Graduate School of Agricultural Science Eugene Futai, Associate ProfessorDoctor of Agriculture Laboratory Website researchmap Laboratory Website researchmap Related Information PublicationsEugene Futai, Sosuke Yagishita, and Shoichi Ishiura, Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific mutations, J. Biol. Chem. 2009, 284, 13013-13022.Eugene Futai, Satoko Osawa, Tesuko Cai, Tomoya Fujisawa, Shoichi Ishiura, and Taisuke Tomita, Specific mutations for presenilin 1 familial Alzheimer disease mutants modulate gamma-secretase activities, J. Biol. Chem. 2016, 291, 435-446. Browsing History Common Keywords MEDICINE DETERMINATION SUPPORT SYSTEM AND MEDICINE DETERMINATION SUPPORT PROGRAM [ 野々垣 勝則 教授 ] IVR (Interventional Radiology) Treatment of Hypertention: Minimally Invasive Treatment of Primary Aldosteronism Based on the Adrenal Vein Sampling Technology [ 高瀬 圭 教授 ] User Who Reviewed This Content Also Reviewed “HYDRIDE" Researches for Energy Applications [ Shin-Ichi Orimo Professor ] [ Chikashi Ishioka Professor ] Visual Computing with Secure ICT in the Big Data Era [ Takafumi Aoki Professor ] Research Profiles ©TOHOKU UNIVERSITY How to Use FAQ For Researchers Site Policy [jp] ©TOHOKU UNIVERSITY Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Fields Themes Researchers 日本語 ENGLISH Close