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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Field Molecular and Chemical Life Science :Chemical Biology Research HOME Research Researcher JAPANESE Professor ISHIKAWA Minoru Campus Katahira campus Laboratory Bioactive Molecules Tel +81-22-217-6197 E-mail minoru.ishikawa.e4＠tohoku.ac.jp Website http://www.agri.tohoku.ac.jp/ishikawa-lab/index.html ORCID: http://orcid.org/0000-0002-3937-2261   Career 2019/Apr - present      Professor   Tohoku University, Graduate School of Life Science 2013/Apr - 2019/Mar   Associate Professor   The University of Tokyo, IMCB, JAPAN 2012/Oct - 2013/Mar   Lecturer   The University of Tokyo, IMCB, JAPAN 2008/Jul - 2012/Sep     Assistant Professor   The University of Tokyo, IMCB, JAPAN 1996/Apr - 2008/Jun    Researcher   Meiji Seika Kaisha. Ltd., JAPAN 2006/Dec                       Ph.D. Pharm.   The University of Tokyo, JAPAN 1994/Apr - 1996/Mar   M.Eng. Tokyo Institute of Technology, JAPAN Graduate School of Bioscience and Biotechnology 1990/Apr - 1994/Mar   B.Eng   Tokyo Institute of Technology, JAPAN School of Bioscience and Biotechnology   Selected Publications Discovery of small molecules that induce degradation of huntingtin Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa* Angewandte Chemie International Edition 2017, 56, 11530-11533. Improving the Water-solubility of Compounds by Molecular Modification to Disrupt Crystal Packing Minoru Ishikawa, Yuichi Hashimoto The Practice of Medicinal Chemistry, 4th edition, ed. by Camille Georges Wermuth, David Aldous, Pierre Raboisson and Didier Rognan, Academic Press: Massachusetts, 2015. pp 747-765. Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry Minoru Ishikawa*, Yuichi Hashimoto Journal of Medicinal Chemistry 2011, 54, 1539-1554. Protein Knockdown Using Methyl Bestatin-ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-mediated Degradation of Cellular Retinoic Acid-Binding Proteins Yukihiro Itoh, Minoru Ishikawa, Mikihiko Naito, Yuichi Hashimoto* Journal of the American Chemical Society 2010, 132, 5820-5826. Activities in Academic Societies the Pharmaceutical Society of Japan; the Chemical Society of Japan; American Chemical Society; the Society of Synthetic Organic Chemistry, Japan; Japanese Society for Chemical Biology Teaching Bioactive Natural Products Chemistry Recent Activities Traditional small molecule drug discovery strategies rely on the “lock and key” theory, which specifies that small molecule drugs bind to target proteins and modulate their functions. However, many disease-related proteins, including substrate binding proteins, aggregation-prone proteins, and protein-protein interactions cannot be predicted by the lock and key mechanism. Therefore, we discovered novel strategies that employ methods of organic chemistry, and molecular and cellular biology to regulate these proteins. We developed a novel strategy for small molecule drug discovery, in which, degradation of target proteins is based on the use of small hybrid molecules composed of a ligand for the target protein and another for ubiquitin ligase. These hybrid small molecules direct the ubiquitin ligase towards the target protein, leading to selective degradation by the ubiquitin-proteasome system. In addition, we demonstrated that this strategy could be an effective therapeutic approach for neurodegenerative diseases. Aqueous solubility is essential for drug candidates, and improving aqueous solubility of bioactive compounds is a major concern for medicinal chemists. We have proposed strategies for improving aqueous solubility by modifying molecules using certain methods that would decrease intermolecular interaction. Our results indicate that these strategies can increase the aqueous solubility of molecules although their hydrophobicities increase concomitantly.   Message to Students Please join our laboratory and let’s enjoy our research together if you want to be an interdisciplinary researcher in organic chemistry and biology, be a researcher a medicinal chemist/chemical biologist, or start a novel research. ResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAward GO TOP Graduate School of Life SciencesTohoku University 2-1-1 Katahira, Aoba-Ku, Sendai 980-8577 Academic Affairs Section Tel : +81-22-217-5706 / Fax: +81-22-217-5704   General Affairs Section Tel : +81-22-217-5702 / Fax: +81-22-217-5704   Contact ・Privacy Policy HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther © 2004-2023 Graduate School of Life Sciences, Tohoku University no cache