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TOP 講座・研究室一覧 呼吸器内科学講座【呼吸器内科学】 講座・研究室 呼吸器内科学講座【呼吸器内科学】 選択してください 教室紹介 研究 教育・医学部教育 スタッフ紹介 業績・主な著書・論文 リンク集 附属病院内の呼吸器内科：順天堂医院｜静岡病院｜浦安病院｜東京江東高齢者医療センター｜練馬病院 教室紹介 当教室は1969年5月に当時虎の門病院呼吸器科部長であった本間日臣教授が初代教授として日本で初めて開設した日本で最も古い歴史を有する呼吸器内科専門教室です。その後、池本秀雄教授、吉良枝郎教授へと引き継がれ、1996年9月には現客員教授である福地義之助教授が主任教授として赴任し、また、2005年8月からは現教授である高橋和久教授が主任教授として教室の運営にあたっております。開講以来、「仁」の精神に裏打ちされた質の高い医療の提供を目標とし、国内で最も古い呼吸器内科専門臨床教室の歴史に基づき、臨床と研究のバランスを保ちつつ多彩な呼吸器疾患に幅広く対応してきております。 対象としている疾患は、呼吸器感染症（かぜ症候群、急性気管支炎、肺炎、誤嚥性肺炎、肺化膿症、肺結核など）、慢性閉塞性肺疾患 （肺気腫、慢性気管支炎）、アレルギー・免疫疾患（気管支喘息、好酸球関連肺疾患、膠原病合併肺疾患、サルコイドーシスなど）、間質性肺疾患（間質性肺炎「肺線維症」、過敏性肺臓炎、塵肺など）、肺腫瘍（原発性肺癌、転移性肺癌、肺良性腫瘍、中皮腫など）、気管支拡張症、びまん性汎細気管支炎、肺リンパ脈管筋腫症（LAM）、肺循環障害（肺血栓塞栓症、肺高血圧症、肺水腫など）、胸膜疾患（胸水、気胸など）、縦隔疾患（縦隔腫瘍など）、結核後遺症、慢性呼吸不全（在宅酸素療法など）、睡眠時無呼吸症候群、慢性咳嗽など多岐にわたります。 呼吸器専門医教育、育成、研究にも力を入れており、学内のカンファレンス（外科、病理、放射線科）、学内共同臨床研究（膠原病と間質性肺炎、肺癌化学療法臨床試験、嚥下障害の研究、呼吸リハビリテーションなど）、他施設との臨床検討会でも指導的立場にあります。診断、治療では、外科、放射線科や各科との連携がスムーズに行われています。 研究 呼吸器疾患の研究は、多岐にわたっており、その研究対象は豊富です。現在、当科では総勢29名が大学院博士課程に在籍し、基礎あるいは臨床研究に取り組んでいます。個人の学問的興味により下記の研究グループを選択し、各専門領域のスーパーバイザーによるきめ細かい指導のもと学位論文を作成、投稿します。各研究グループの研究テーマに関しては、以下のリンク先をご参照ください。 肺腫瘍グループ　基礎研究 肺腫瘍グループ　臨床研究 LAM（肺リンパ脈管筋腫症)グループ COPDグループ 気管支喘息グループ 肺循環生理グループ 間質性肺疾患グループ 肺疾患線維化テロメア活性病態研究グループ 呼吸管理（睡眠時無呼吸症候群、呼吸不全、呼吸生理）グループ そして毎年、定期的に5～7名に医学博士が授与されています（写真1）。またインドネシア大学（国費留学生）など海外からも留学生が来ており、当科の医局員・大学院生らと積極的に交流しています。定期的にリサーチ・ミーティングも行っており、高橋教授・瀬山教授らの指導を受けることができます。当科では広い研究専用のLaboratoryを有しており、基礎研究を行う設備が充実しています（写真2）。また個々の大学院生が論文を読み、論文を書くためのデスクも完備しており、落ち着いて学問をする環境が整っています（写真3）。基礎研究だけでなく、臨床データや画像を解析する臨床研究も同時に精力的に展開しています（写真4）。世界的なCOVID-19感染拡大により、現在は難しい状況ですが、大学院修了後、ポスドクとしてさらなるステップアップを目指す場合には、ハーバード大学医学部、オハイオ州立大学、ミシガン大学などへの海外留学も積極的に推進しています。そして基礎研究で得られた知識と技術を臨床医学に応用し、難治性呼吸器疾患の予防・診断・治療に寄与すること、そして医学の発展に貢献することを目標としています。 教育・医学部教育 大学院はいずれの時点でも入学が可能です。だたし、当科は臨床教室でもあるため一定期間の臨床経験を推奨しており、内科専門医取得の時期、いわゆる後期研修終了以降の入学を原則としております。現在、総勢25名が在籍しており、当科で研究しているもの以外に、他施設に国内留学して研究を行っている者もおります。大学院生は入学後4年間で学位の取得が可能です。大学院進学の場合、1年次は病棟臨床研修、2～3年次は学位取得のための基礎または臨床研究、そして4年次に学位論文の作成を行っています。通常は4年間の過程で大学院卒業ですが、よい論文が作成されれば3年間での卒業も可能です。もちろん、大学院コースを選択した場合も各種専門医の取得を励行しています。 個人の学問的興味により下記の研究グループを選択し、各専門領域のスーパーバイザーによるきめ細かい指導を受けます。各研究グループの研究テーマに関しては、以下のリンク先をご参照ください。 肺腫瘍グループ　基礎研究 肺腫瘍グループ　臨床研究 LAM（肺リンパ脈管筋腫症)グループ COPDグループ 気管支喘息グループ 肺循環生理グループ 間質性肺疾患グループ 肺疾患線維化テロメア活性病態研究グループ 呼吸管理（睡眠時無呼吸症候群、呼吸不全、呼吸生理）グループ スタッフ紹介 教授 経歴昭和60年 順天堂大学医学部卒業専門分野肺癌 髙橋 和久（たかはし かずひさ） 医学部・大学院医学研究科：教授順天堂大学医学部長・医学研究科長順天堂医院：呼吸器内科 経歴平成3年 順天堂大学医学部卒業専門分野感染症,感染制御 堀 賢（ほり さとし） 医学部：教授大学院医学研究科：感染制御学教授順天堂医院：感染対策室室長 経歴平成1年 順天堂大学医学部卒業専門分野肺癌、感染症 岩神 真一郎（いわかみ しんいちろう） 医学部・大学院医学研究科：教授静岡病院：呼吸器内科 経歴昭和63年 順天堂大学医学部卒業専門分野肺癌、感染症、間質性肺炎 佐々木 信一（ささき しんいち） 医学部・大学院医学研究科：教授浦安病院：呼吸器内科 客員教授 経歴昭和57年 北海道大学医学部卒業専門分野慢性閉塞性肺疾患(COPD）、リンパ脈管筋腫症、嚢胞性肺疾患 瀬山 邦明（せやま くにあき） 医学部・大学院医学研究科：客員教授順天堂医院：呼吸器内科 経歴昭和59年 順天堂大学医学部卒業専門分野呼吸生理、慢性呼吸不全 鈴木 勉（すずき つとむ） 医学部：客員教授医学部医学教育研究室：客員教授（併任） 経歴平成5年 順天堂大学医学部卒業専門分野肺癌基礎研究、薬剤耐性 高橋 史行（たかはし ふみゆき） 医学部・大学院医学研究科：客員教授順天堂医院：呼吸器内科 先任准教授 経歴平成5年 順天堂大学医学部卒業専門分野慢性閉塞性肺疾患(COPD）、気管支喘息 児玉 裕三（こだま ゆうぞう） 医学部・大学院医学研究科：先任准教授順天堂医院：呼吸器内科 准教授 経歴平成6年 順天堂大学医学部卒業専門分野肺循環障害、気管支鏡 長岡 鉄太郎（ながおか てつたろう） 医学部・大学院医学研究科：准教授順天堂医院：呼吸器内科 経歴平成6年 順天堂大学医学部卒業専門分野肺癌、肺線維芽細胞、胸部超音波 十合 晋作（とうごう しんさく） 医学部・大学院医学研究科：准教授順天堂医院：呼吸器内科 経歴平成6年 筑波大学医学専門学群卒業専門分野睡眠呼吸障害、呼吸管理 塩田 智美（しおた さとみ） 医学部・大学院医学研究科：准教授順天堂医院：呼吸器内科 経歴平成7年 順天堂大学医学部卒業専門分野気管支喘息 原田 紀宏（はらだ のりひろ） 医学部・大学院医学研究科：准教授順天堂医院：呼吸器内科 経歴平成7年 山梨医科大学卒業専門分野化学療法、呼吸器一般 嶋田 奈緒子（しまだ なおこ） 医学部・大学院医学研究科：准教授（教育）順天堂医院：呼吸器内科 経歴平成10年 岡山大学医学部卒業専門分野慢性閉塞性肺疾患(COPD） 佐藤 匡（さとう ただし） 医学部・大学院医学研究科：准教授順天堂医院：呼吸器内科　医局長 経歴平成12年 順天堂大学医学部卒業専門分野肺癌 田島 健（たじま けん） 医学部・大学院医学研究科：准教授順天堂医院：呼吸器内科 経歴平成14年 山梨医科大学医学部卒業専門分野肺癌 宿谷 威仁（しゅくや たけひと） 医学部・大学院医学研究科：准教授順天堂医院：呼吸器内科 経歴平成10年 順天堂大学医学部卒業専門分野喘息、COPD 長島 修（ながしま おさむ） 医学部・大学院医学研究科：准教授浦安病院：呼吸器内科 経歴平成15年 帝京大学医学部卒業専門分野気管支喘息、慢性閉塞性肺疾患(COPD) 牧野 文彦（まきの ふみひこ） 医学部・大学院医学研究科：准教授浦安病院：呼吸器内科 経歴平成15年 順天堂大学医学部卒業専門分野緩和医療 菅野 康二（すがの こうじ） 医学部・大学院医学研究科：准教授東京江東高齢者医療センター：呼吸器内科 経歴平成3年 山梨医科大学医学部卒業専門分野気管支喘息、慢性閉塞性肺疾患(COPD） 木戸 健治（きど けんじ） 医学部・大学院医学研究科：准教授練馬病院：呼吸器内科 経歴平成11年 杏林大学卒業専門分野肺癌 小山 良（こやま りょう） 医学部・大学院医学研究科：准教授練馬病院：呼吸器内科 経歴平成14年 横浜市立大学医学部卒業専門分野肺癌、緩和医療 八戸 敏史（やえ としふみ） 医学部・大学院医学研究科：准教授練馬病院：呼吸器内科 客員准教授 経歴昭和59年 山形大学医学部卒業専門分野呼吸器内科一般、肺高血圧症 大和田 明彦（おおわだ あきひこ） 医学部：客員准教授 講師 経歴平成17年 浜松医科大学医学部卒業専門分野肺感染症 南條 友央太（なんじょう ゆうた） 医学部・大学院医学研究科：講師浦安病院：呼吸器内科 経歴平成18年 順天堂大学医学部卒業専門分野呼吸器内科一般、肺癌 難波 由喜子（なんば ゆきこ） 医学部・大学院医学研究科：講師浦安病院：がん治療センター(出向) 助教 経歴平成15年 順天堂大学医学部卒業専門分野慢性閉塞性肺疾患(COPD) 小池 建吾（こいけ けんご） 医学部：助教順天堂医院：呼吸器内科 経歴平成15年 東北大学医学部卒業専門分野肺癌 光石 陽一郎（みついし よういちろう） 医学部：助教順天堂医院：呼吸器内科 経歴平成16年 岐阜大学医学部卒業専門分野肺癌 三森 友靖（みもり ともやす） 医学部：助教順天堂医院：呼吸器内科 経歴平成18年 埼玉医科大学医学部卒業専門分野間質性肺炎 加藤 元康（かとう もとやす） 医学部：助教順天堂医院：呼吸器内科 経歴平成19年 高知大学医学部卒業専門分野呼吸器一般、肺癌 嶋村 尚子（しまむら　しょうこ） 医学部：助教順天堂医院：呼吸器内科 経歴平成20年 東京医科大学医学部卒業専門分野肺癌 金丸 良太（かねまる りょうた） 医学部：助教順天堂医院：呼吸器内科 経歴平成23年 筑波大学医学部卒業専門分野肺癌 宮脇 太一（みやわき たいち） 医学部：助教順天堂医院：呼吸器内科 経歴平成23年 順天堂大学医学部卒業専門分野呼吸器一般、COPD 新田 直子（にった　なおこ） 医学部：助教順天堂医院：呼吸器内科 　 経歴平成24年 順天堂大学医学部卒業専門分野気管支喘息、呼吸器一般 笹野 仁史（ささの ひとし） 医学部：助教順天堂医院：呼吸器内科 経歴平成12年 順天堂大学医学部卒業専門分野呼吸器内科一般 岩神 直子（いわかみ なおこ） 医学部：助教静岡病院：呼吸器内科 経歴平成23年 順天堂大学医学部卒業専門分野呼吸器一般、肺癌 早川 乃介（はやかわ だいすけ） 医学部：助教静岡病院：呼吸器内科 経歴平成24年 順天堂大学医学部卒業専門分野呼吸器一般、肺高血圧 吉田 隆司（よしだ たかし） 医学部：助教静岡病院：呼吸器内科 経歴平成18年 順天堂大学医学部卒業専門分野慢性閉塞性肺疾患(COPD) 鈴木 洋平（すずき ようへい） 医学部：助教浦安病院：呼吸器内科 経歴平成22年 順天堂大学医学部卒業専門分野呼吸器一般 金森 幸一郎（かねもり　こういちろう） 医学部：助教浦安病院：呼吸器内科 経歴平成24年 順天堂大学医学部卒業専門分野呼吸器一般 中村 洸太（なかむら こうた） 医学部：助教浦安病院：呼吸器内科 経歴平成21年 順天堂大学医学部卒業専門分野気管支喘息 松野 圭（まつの けい） 医学部：助教東京江東高齢者医療センター：呼吸器内科 経歴平成23年 順天堂大学医学部卒業専門分野気管支喘息 竹重 智仁（たけしげ ともひと） 医学部：助教練馬病院：呼吸器内科 経歴平成22年 秋田大学医学部卒業専門分野呼吸器内科一般 渡邊 純子（わたなべ じゅんこ） 医学部：助教練馬病院：呼吸器内科 助手 経歴平成22年 順天堂大学医学部卒業専門分野呼吸器一般 濃沼 淑芳（こいぬま よしか） 医学部：助手順天堂医院：呼吸器内科 名誉教授 経歴昭和39年 群馬大学医学部卒業専門分野慢性閉塞性肺疾患(COPD）、誤嚥性肺疾患 福地 義之助（ふくち よしのすけ） 名誉教授 経歴昭和41年 順天堂大学医学部卒業専門分野呼吸器内科一般、慢性気道感染症 稲冨 惠子（いなとみ けいこ） 名誉教授 経歴昭和58年 順天堂大学医学部卒業専門分野呼吸リハビリテーション、慢性閉塞性肺疾患(COPD) 植木 純（うえき じゅん） 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North East Japan Study Group. Clinical Outcomes of Second-Line Chemotherapy in Patients with Previously Treated Advanced Thymic Carcinoma: A Retrospective Analysis of 191 Patients from the NEJ023 Study. Oncologist 25(4): e668-e674. 2020 Apr Sekine I, Shintani Y, Shukuya T, Takayama K, Inoue A, Okamoto I, Kiura K, Takahashi K, Dosaka-Akita H, Takiguchi Y, Miyaoka E, Okumura M, Yoshino I. A Japanese lung cancer registry study on demographics and treatment modalities in medically treated patients. Cancer Sci. 111(5):1685-1691, 2020 May Wang K, Verbakel JY, Oke J, Fleming-Nouri A, Brewin J, Roberts N, Harada N, Atsuta R, Takahashi K, Mori K, Fujisawa T, Shirai T, Kawayama T, Inoue H, Lazarus S, Szefler S, Martinez F, Shaw D, Pavord ID, Thomas M. Using fractional exhaled nitric oxide to guide step-down treatment decisions in patients with asthma: a systematic review and individual patient data meta-analysis. Eur Respir J. 55(5):1902150, 2020 May Okamoto S, Suzuki K, Hayashi T, Muraki K, Nagaoka T, Nishino K, Sekimoto Y, Sasaki S, Takahashi K, Seyama K. Transbronchial lung biopsy for the diagnosis of lymphangioleiomyomatosis: the severity of cystic lung destruction assessed by the modified Goddard scoring system as a predictor for establishing the diagnosis. Orphanet J Rare Dis 15(1):125, 2020 May Kohsaka S, Hayashi T, Nagano M, Ueno T, Kojima S, Kawazu M, Shiraishi Y, Kishikawa S, Suehara Y, Takahashi F, Takahashi K, Suzuki K, Takamochi K, Mano H. Identification of Novel CD74-NRG2αFusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers. J Thorac Oncol 15(6):948-961, 2020 Jun Kozuki T, Nogami N, Hataji O, Tsunezuka Y, Seki N, Harada T, Fujimoto N, Bessho A, Takamura K, Takahashi K, Satouchi M, Kato T, Shukuya T, Yamashita N, Okamoto H, Shinkai T, Thoracic Oncology Research Group. Open-label, multicenter, randomized phase II study on docetaxel plus bevacizumab or pemetrexed plus bevacizumab for treatment of elderly (aged ≥ 75 years) patients with previously untreated advanced non-squamous non-small cell lung cancer: TORG1323. Transl Lung Cancer Res 9(3): 459-470, 2020 Jun Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nat Genet. 52(7):669-679, 2020 Jun Ihara H, Mitsuishi Y, Kato M, Takahashi F, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa SI, Suzuki K, Takahashi K. Nintedanib Inhibits Epithelial-Mesenchymal Transition in A549 Alveolar Epithelial Cells Through Regulation of the TGF-β/Smad Pathway. Respir Investig 58(4): 275-284, 2020 Jul Kobayashi K, Soejima K, Fukunaga K, Shintani Y, Sekine I, Shukuya T, Takayama K, Inoue A, Okamoto I, Kiura K, Takahashi K, Yamamoto N, Takiguchi Y, Miyaoka E, Okumura M, Yoshino I, and on behalf of the Group on behalf of the Japanese Joint Committee of Lung Cancer Registry. Key prognostic factors for EGFR-mutated non-adenocarcinoma lung cancer patients in the Japanese Joint Committee of Lung Cancer Registry Database. Lung Cancer 146: 236-243, 2020 Aug Igawa S, Naoki K, Shintani Y, Sekine I, Shukuya T, Takayama K, Inoue A, Okamoto I, Kiura K, Takahashi K, Yamamoto N, Takiguchi Y, Miyaoka E, Okumura M, Yoshino I. Survival and Prognostic Factors in Elderly Patients Receiving Second-line Chemotherapy for Relapsed Small-Cell Lung Cancer: Results from the Japanese Joint Committee of Lung Cancer Registry. Lung Cancer. 146: 160-164, 2020 Aug Harada N, Harada S, Ito J, Atsuta R, Hori S, Takahashi K. Mobile Health App for Japanese Adult Patients With Asthma: Clinical Observational Study. J Med Internet Res. 22(8):e19006, 2020 Aug 14 Miyawaki T, Kenmotsu H, Mori K, Miyawaki E, Mamesaya N, Kawamura T, Kobayashi H, Omori S, Wakuda K, Ono A, Naito T, Murakami H, Harada H, Endo M, Ohde Y, Takahashi K, Takahashi T. Association Between Clinical Tumor Burden and Efficacy of Immune Checkpoint Inhibitor Monotherapy for Advanced Non-Small-Cell Lung Cancer. Clin Lung Cancer. 21(5): e405-e414, 2020 Sep Hayashi T, Kohsaka S, Takamochi K, Hara K, Kishikawa S, Sano K, Takahashi F, Suehara Y, Saito T, Takahashi K, Suzuki K, Yao T. Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations. Hum Pathol. 103:42-51, 2020 Sep Takei S, Ihara H, Togo S, Nakamura A, Fujimoto Y, Watanabe J, Kurokawa K, Shibayama K, Sumiyoshi I, Ochi Y, Iwai M, Okabe T, Chonan M, Misawa S, Ohsaka A, Takahashi K. The synergetic effect of Imipenem-clarithromycin combination in the Mycobacteroides abscessus complex. BMC Microbiol. 20(1):316, 2020 Oct 19 Okuma Y, Ko R, Shukuya T, Tateishi K, Imai H, Iwasawa S, Miyauchi E, Kojima T, Fujita Y, Hino T, Yamanda S, Suzuki T, Fukuizumi A, Sakakibara T, Harada T, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group. Prognostic factors for patients with metastatic or recurrent thymic carcinoma receiving palliative-intent chemotherapy. Lung Cancer. 148:122-128, 2020 Oct Kato M, Takahashi F, Sato T, Mitsuishi Y, Tajima K, Ihara H, Nurwidya F, Baskoro H, Murakami A, Kobayashi I, Hidayat M, Shimada N, Sasaki S, Mineki R, Fujimura T, Kumasaka T, Niwa S, Takahashi K. Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway. Drug Des Devel Ther. 14: 4593-4603, 2020 Oct 29 Tsuboshima K, Kurihara M, Yamanaka T, Watanabe K, Matoba Y, Seyama K. Does a gender have something to do with clinical pictures of primary spontaneous pneumothorax？ Gen　Thorac Cardiovasc Surg. 68(8):741-745, 2020. Suzuki K, Seyama K, Ebana H, Kumasaka T, Kuwatsuru R. Quantitative analysis of cystic lung diseases by use of paired inspiratory and expiratory CT: estimation of the extent of cyst-airway communication and evaluation of diagnostic utility. Radiology: Cardiothoracic Imaging. 2: e190097, 2020 Suzuki E, Kurihara M, Tsuboshima K, Watanabe K, Okamoto S, Seyama K. The effects of total pleural covering on pneumothorax recurrence and pulmonary function in lymphangioleiomyomatosis patients without history of pleurodesis or thoracic surgeries for pneumothorax. J Thorac Dis in press, 2020. Miyazaki K, Togo S, Okamoto R, Idiris A, Kumagai H, Miyagi Y. Collective cancer cell invasion in contact with fibroblasts through integrin-α5β1/fibronectin interaction in collagen matrix. Cancer Sci. 2020 Sep 26. Wang K, Verbakel JY, Oke J, Fleming-Nouri A, Harada N, Atsuta R, Fujisawa T, Kawayama T, Inoue H, Lazarus S, Szefler S, Martinez FD, Shaw D, Pavord ID, Thomas M. Using fractional exhaled nitric oxide to guide step-down treatment decisions in asthma: practical considerations. Eur Respir J 2020; 56: 2002809. Mikawa R, Sato T, Suzuki Y, Baskoro H, Kawaguchi K, Sugimoto M. p19Arf exacerbates cigarette smoke-induced pulmonary dysfunction. Biomolecules 10(3), 462. (2020) Llabata P, Mitsuishi Y, Choi PS, Cai D, Francis JM, Torres-Diz M, Udeshi ND, Golomb L, Wu Z, Zhou J, Svinkina T, Aguilera-Jimenez E, Liu Y, Carr SA, Sanchez- Cespedes M, Meyerson M, Zhang X. Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma. Mol Cancer Res. 2020 Apr;18(4):574-584. Sakamoto S, Kataoka K, Kondo Y, Kato M, Okamoto M, Mukae H, Bando M, Suda T, Yatera K, Tanino Y, Kishaba T, Hattori N, Taguchi Y, Saito T, Nishioka Y, Kuwano K, Kishi K, Inase N, Sasaki S, Takizawa H, Johkoh T, Sakai F, Homma S; Diffuse Lung Diseases Research Group of the Ministry of Health, Labour and Welfare, Japan. Pirfenidone plus inhaled N-acetylcysteine for idiopathic pulmonary fibrosis: a randomised trial. Eur Respir J. 2020 Jul 23:2000348. Tanaka K, Morita S, Ando M, Yokoyama T, Nakamura A, Yoshioka H, Ishiguro T, Miura S, Toyozawa R, Oguri T, Daga H, Ko R, Bessho A, Tashihara M, Iwamoto Y, Hirano K, Nakanishi Y, Nakagawa K, Yamamoto N, Okamoto I. A randomized phase 3 study of maintenance therapy with S-1 plus best supportive care versus best supportive care after induction therapy with carboplatin plus S-1 for advanced or relapsed squamous cell carcinoma of the lung (WJOG7512L). Cancer 2020; 125: 3648-3656. Shukuya T, Ghai V, Amann JM, Okimoto T, Shilo K, Kim TK, Wang K, Carbone DP. Circulating MicroRNAs and Extracellular Vesicle-Containing MicroRNAs as Response Biomarkers of Anti-programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC. J Thorac Oncol. 2020 Nov;15(11):1773-1781. Shukuya T, Oyanagi J, Serizawa M, Watanabe M, Yamamoto N, Koh Y. Hypoxia Inducible Factor-1α Inhibition in Von Hippel Lindau-mutant Malignant Pleural Mesothelioma Cells. Anticancer Res. 2020 Apr;40(4):1867-1874. Yamauchi M, Nakayama H, Shiota S, Ohshima Y, Terada J, Nishijima T, Kosuga M, Kitamura T, Tachibana N, Oguri T, Shirahama R, Aoki Y, Ishigaki K, Sugie K, Yagi T, Muraki H, Fujita Y, Takatani T, Muro S. Potential patient screening for late-onset Pompe disease in suspected sleep apnea: a rationale and study design for a Prospective Multicenter Observational Cohort Study in Japan (PSSAP-J Study). Sleep Breath. 2020 Aug 18. Online ahead of print. Sata N, Inoshita A, Suda S, Shiota S, Shiroshita N, Kawana F, Suzuki Y, Matsumoto F, Ikeda K, Kasai T. Clinical, polysomnographic, and cephalometric features of obstructive sleep apnea with AHI over 100. Sleep Breath. 2020 Nov 17. Online ahead of print. Nakagawa K, Hida T, Nokihara H, Morise M, Azuma K, Kim Y.K, Seto T, Takiguchi Y, Nishio M, Yoshioka H, Kumagai T, Hotta K, Watanabe S, Goto K, Satouchi M, Kozuki T, Koyama R, Mitsudomi T, Yamamoto N, Asakawa T, Hayashi M, Hasegawa W, Tamura T．Final progression-free survival results from the J-ALEX study of alectinib versus crizotinib in ALK-positive non-small-cell lung cancer. Lung Cancer., 2020 Jan; 139: 195-199. Nakazawa Y, Sakashita A, Kaizu M, Abo H, Ise Y, Shinada Y, Sugano K, Yamashiro A, Akizuki N, Kato M. A Self-Check Program Targeting Quality Improvement in a Hospital-Based Palliative Care Consultation Team, Japanese Society for Palliative Medicine: Issues Regarding Team Activities Identified through the Plan-Do-Check-Act Cycle. J Palliat Med. 2020 Mar; 23(3):359-367 Matsuda Y, Tanimukai H, Inoue S, Inada S, Sugano K, Hasuo H, Yoshimura M, Wada S, Dotani C, Adachi H, Okamoto Y, Takeuchi M, Fujisawa D, Kako J, Sasaki C, Kishi Y, Akizuki N, Inagaki M, Uchitomi Y, Matsushima E, Okuyama T. JPOS/JASCC clinical guidelines for delirium in adult cancer patients: a summary of recommendation statements. Jpn J Clin Oncol 2020 May; 50(5): 586-593 Kogami M, Suzuki S, Nanjo Y, Ikeda K, Tamura N, Sasaki S, Morimoto S. Complication of coronavirus disease 2019 during remission induction therapy against anti-MDA5 antibody-positive dermatomyositis. Rheumatol Adv Pract. 4(2): rkaa068, 2020 Nov Sugiyama AI, Shiota S, Yamada T, Ito J, Suzuki K, Takahashi K. Sleep-related breathing disorders associated with the characteristics of underlying congenital rare diseases of Moebius syndrome and Poland syndrome. Respirol Case Rep 8(5): e00579, 2020 May Jingo K, Harada N, Nishioki T,Torasawa M,Yamada T, Asao T, Takagi T,Takeshige T, Ito J, Takahashi K. Anaphylaxis to three humanized antibodies for severe asthma: A case study. Allergy Asthma Clin Immunol. 10;16:46. eCollection 2020 Jun Kato Y, Kato M, Ihara H, Hayakawa E, Shibayama K, Miura K, Yamada T, Mitsuishi Y, Shukuya T, Ito J, Matsunaga T, Sato T, Suzuki K, Takahashi K. Hermansky-Pudlak syndrome-associated pneumothorax with rapid progression of respiratory failure: a case report. BMC Pulm Med. 20(1):259, 2020 Oct Nishioki T, Kato M, Kataoka S, Miura K, Nagaoka T, Takahashi K. Atezolizumab‐induced fulminant type 1 diabetes mellitus occurring four months after treatment cessation. Respirology Case Reports. 8(9):doi.org/10.1002/rcr2.685, 20020 Oct Kurokawa K, Harada N, Sasano H, Takahagi H, Takei S, Nakamura A, Kamada K, Yoshida A, Kikuchi K, Takahashi K. Pulmonary infection due to fluoroquinolone-resistant Mycolicibacterium fortuitum: a case report. BMC Infectious Diseases. 20: 866, 2020 Nov Ochi Y, Kato M, Fujioka M, Hayashi M, Takagi H, Takahashi K. Thrombocytopaenia during nintedanib treatment in a patient with idiopathic pulmonary fibrosis. Respirol Case Rep. 2020, 8: e00628. Kurata K, Matsumoto H, Jimbo N, Yakushijin K, Yamamoto K, Ito M, Nakamachi Y,　Matsuoka H, Saegusa J, Seyama K, Itoh T, Minami H. Lymphoplasmacytic lymphoma in a patient with Birt-Hogg-Dubé syndrome. Int J Hematol. 2020 Dec;112(6):864-870. Hayashi T, Takamochi K, Kohsaka S, Kishikawa S, Suehara Y, Takahashi F, Suzuki K, Saito T. Spontaneous transformation from EGFR/PTEN co-mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis. Pathol Int 70(5):295-299 (2020) Kumakawa Y, Hirano Y, Sueyoshi K, Ishihara T, Kondo Y, Kawasaki T, Takeuchi Y, Nakamura Y, Ishikawa K, Watanabe Y, Saito W, Matsuda S, Nakazawa T, Sasaki S, Okamoto K, Hiroshi T. Late i.v. steroid treatment for severe COVID-19-induced acute respiratory distress syndrome: a case report. Acute Med Surg., 7(1): e569, 2020 Sep Hayama N, Ihara H, Honma Y, Itoigawa Y, Kaira K, Fujii M: Severe gastritis due to pembrolizumab treatment in a lung cancer patient. Respirol Case Rep. 8(7) : e00636, 2020 Oct 英文業績（2019） Tsutsumi T, Nagaoka T, Yoshida T, Wang L, Kuriyama S, Suzuki Y, Nagata Y, Harada N, Kodama Y, Takahashi F, Morio Y, Takahashi K. Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation. PLoS one 24;14(7):e0214697. eCollection 2019. Kadoya K, Togo S, Tulafu M, Namba Y, Iwai M, Watanabe J, Okabe T, Jin J, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Takeda T, Kondo N, Takahashi K. Specific features of fibrotic lung fibroblasts highly sensitive to fibrotic processes mediated via TGF-β-ERK5 interaction. Cell Physiol Biochem. 52(4):822-837, 2019 Jun　 Tajima K, Matsuda S, Yae T, Drapkin BJ, Morris R, Boukhali M, Niederhoffer K, Comaills V, Dubash T, Nieman L, Guo H, Magnus NKC, Dyson N, Shioda T, Haas W, Haber DA, Maheswaran S. SETD1A protects from senescence through regulation of the mitotic gene expression program. Nat Commun. 2019 Jun 28;10(1):2854. Shukuya T, Yamada T, Koenig MJ, Xu J, Okimoto T, Li F, Amann JM, Carbone DP. The Effect of LKB1 Activity on the Sensitivity to PI3K/mTOR Inhibition in Non-Small Cell Lung Cancer. J Thorac Oncol. 2019 Jun;14(6):1061-1076. Epub 2019 Kitajima S, Ivanova E, Guo S, Yoshida R, Campisi M, Sundararaman SK, Tange S, Mitsuishi Y, Thai TC, Masuda S, Piel BP, Sholl LM, Kirschmeier PT, Paweletz CP, Watanabe H, Yajima M, Barbie DA. Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer. Cancer Discov. 2019 Jan;9(1):34-45. Epub 2018 Oct 8. Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H. Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens. Cancer Sci. 110(4):1464-1479, 2019 Apr Koike K, Berdyshev EV, Mikosz AM, Bronova IA, Bronoff AS, Jung JP, Beatman EL, Ni K, Cao D, Scruggs AK, Serban KA, Petrache I. Role of Glucosylceramide in Lung Endothelial Cell Fate and Emphysema. Am J Respir Crit Care Med. 2019 Nov 1;200(9):1113-1125. doi: 10.1164/rccm.201812-2311OC. Kato M, Sasaki S, Nakamura T, Kurokawa K, Yamada T, Ochi Y, Ihara H, Takahashi F, Takahashi K. Gastrointestinal adverse effects of nintedanib and the associated risk factors in patients with idiopathic pulmonary fibrosis. Scientific Reports 19;9(1):12062. 2019. Kato M, Sasaki S, Kurokawa K, Nakamura T, Yamada T, Sasano H, Arano N, Komura M, Ihara H, Nagashima O, Shiota S, Takahashi F, Takahashi K. Usual interstitial pneumonia pattern in the lower lung lobes as a prognostic factor in idiopathic pleuroparenchymal fibroelastosis. Respiration. 97(4):319-328, 2019 Jan Tateishi K, Ko R, Shukuya T, Okuma Y, Watanabe S, Kuyama S, Murase K, Tsukita Y, Ashinuma H, Nakagawa T, Uematsu K, Nakao M, Mori Y, Kaira K, Mouri A, Miyabayashi T, Sakashita H, Matsumoto Y, Tanigawa T, Koizumi T, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group. Clinical Outcomes of Second-Line Chemotherapy in Patients with Previously Treated Advanced Thymic Carcinoma: A Retrospective Analysis of 191 Patients from the NEJ023 Study. Oncologist. 2019 Nov 26. pii: theoncologist.2019-0593. [Epub ahead of print] Seyama K, Nukiwa T, Sato T, Suzuki M, Konno S, Takahashi K, Nishimura M, Steinmann K, Sorrells S, Chen J, Hayashi KI. Safety and pharmacokinetics of Alpha-1 MP (Prolastin®-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency. Respir Investig. 57(1):89-96, 2019 Jan　 Yamaguchi Y, Shiota S, Kusunoki Y, Hamaya H, Ishii M, Kodama Y, Akishita M, Kida K, Takahashi K, Nagase T, Fukuchi Y. Polysomnographic features of low arousal threshold in overlap syndrome involving obstructive sleep apnea and chronic obstructive pulmonary disease. Sleep Breath. 2019 Jan 26. [Epub ahead of print]　 Tanabe Y, Harada N, Ito J, Matsuno K, Takeshige T, Harada S, Takemasa M, Kotajima M, Ishimori A, Katsura Y, Makino F, Atsuta R, Takahashi K. Difference between two exhaled nitric oxide analyzers, NIOX VERO® electrochemical hand-held analyzer and NOA280i® chemiluminescence stationary analyzer. J Asthma. 56(2):167-172, 2019 Feb Kuwasaki E, Nagaoka T, Ihara H, Tsutsumi T, Nakamura A, Yoshikawa H, Yoshida T, Watanabe J, Ichikawa M, Koyama R, Shimada N, Takahashi K. Age is an independent predictor in pathological diagnosis of sarcoidosis: a retrospective analysis of diagnosis by endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Dis. 11(5):2175-2180, 2019 May Hidayat M, Mitsuishi Y, Takahashi F, Tajima K, Yae T, Miyahara K, Hayakawa D, Winardi W, Ihara H, Koinuma Y, Wirawan A, Nurwidya F, Kato M, Kobayashi I, Sasaki S, Takamochi K, Hayashi T, Suehara Y, Moriyama M, Moriyama H, Habu S, Takahashi K. Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer. Bosn J Basic Med Sci. 2019 May 28. [Epub ahead of print] Jin J, Togo S, Kadoya K, Tulafu M, Namba Y, Iwai M, Watanabe J, Nagahama K, Okabe T, Hidayat M, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Sasaki S, Tominaga S, Takahashi K. Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1. Respir Res. 20(1):119, 2019 Jun 11 Nanjo Y, Newstead MW, Aoyagi T, Zeng X, Takahashi K, Yu FS, Tateda K, Standiford TJ. Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against Murine Legionella pneumophila Pneumonia. Infect Immun. 19;87(1). pii: e00583-18. 2019 Zuoyou L, Shiota S, Morio Y, Sugiyama A, Sekiya M, Iwakami SI, Ienaga H, Fukuchi Y, Takahashi K. Borderline pulmonary hypertension associated with chronic hypercapnia in chronic pulmonary disease. Respir Physiol Neurobiol. 2019 Apr;262:20-25. Epub 2019 Ihara H, Kikuchi K, Taniguchi H, Fujita S, Tsuruta Y, Kato M, Mitsuishi Y, Tajima K, Kodama Y, Takahashi F, Takahashi K, Azuma N. 23-valent pneumococcal polysaccharide vaccine improves survival in dialysis patients by preventing cardiac events. Vaccine. 2019 Oct 8;37(43):6447-6453. Epub 2019 Karasutani K, Baskoro H, Sato T, Arano N, Suzuki Y, Mitsui A, Shimada N, Kodama Y, Seyama K, Fukuchi Y, Takahashi K. Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice. J Vis Exp. 2019 Sep 26;(151). Shoji T, Konno S, Niida Y, Ogi T, Suzuki M, Shimizu K, Hida Y, Kaga K, Seyama K, Naka T, Matsuno Y, Nishimura M. Familial multifocal micronodular pneumocyte hyperplasia with a novel splicing mutation in TSC1: Three cases in one family. PLoS One. 2019 Feb 22;14(2):e0212370. eCollection 2019. Oba S, Inaba Y, Shibuya T, Oshima J, Seyama K, Kobayashi T, Kunugita N, Ino T. Changes in oxidative stress levels during two weeks of smoking cessation treatment and their association with nutritional characteristics in Japanese smokers. Exp Ther Med. 2019 Apr;17(4):2757-2764. Epub 2019 Tsuyama S, Saito T, Akazawa Y, Yanai Y, Yatagai N, Akaike K, Hayashi T, Suehara Y, Takahashi F, Takamochi K, Hashimoto T, Kajiyama Y, Tsurumaru M, Fukunaga T, Yao T. Molecular and clinicopathological analyses of esophageal carcinosarcoma with special reference to morphological change. Virchows Archiv ;475(4):415-424. Epub 2019 Aug 23. Suehara Y, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Sano K, Hasegawa N, Miura Y, Akaike K, Kim Y, Takamochi K, Takahashi F, Ueno T, Kaneko K, Saito T. Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone. Proteomics Clin Appl. e1800147. (2019) Miyazaki K, Oyanagi J, Hoshino D, Togo S, Kumagai H, Miyagi Y. Cancer cell migration on elongate protrusions of fibroblasts in collagen matrix. Sci Rep. 2019 Jan 22;9(1):292. Maruyama N, Takai T, Kamijo S, Suchiva P, Ohba M, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Harada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy. 2019 Nov;74(11):2237-2240. Epub 2019 Mizugaki H, Hamada A, Shibata T, Hosoda F, Nakamura H, Okuma Y, Shukuya T, Umemura S, Horiike A, Fukui T, Kogure Y, Daga H, Urata Y, Yamada K, Saeki S, Fujisaka Y, Nakamura Y, Sato M, Yoshida T, Hotta T, Oizumi S, Fujiwara Y, Ohe Y, Fujiwara Y. Exploration of germline variants responsible for adverse events of crizotinib in anaplastic lymphoma kinase-positive non-small cell lung cancer by target-gene panel sequencing. Lung Cancer. 2019 Feb;128:20-25. Yoh K, Takamochi K, Shukuya T, Hishida T, Tsuboi M, Sakurai H, Goto Y, Yoshida K, Ohde Y, Okumura S, Ohashi Y, Kunitoh H. Pattern of care in adjuvant therapy for resected Stage I non-small cell lung cancer: real-world data from Japan. Jpn J Clin Oncol. 2019 Jan 1;49(1):63-68. Kenmotsu H, Yoh K, Mori K, Ono A, Baba T, Fujiwara Y, Yamaguchi O, Ko R, Okamoto H, Yamamoto N, Ninomiya T, Ogura T, Kato T. Phase II study of nab-paclitaxel + carboplatin for patients with non-small-cell lung cancer and interstitial lung disease. Cancer Sci. 2019 Dec;110(12):3738-3745. Nakashima K, Kimura M, Akamatsu H, Daga H, Imai H, Taira T, Ko R, Hisamatsu Y, Nishino K, Sugimoto T, Miyashita Y, Takahashi T. Osimertinib for patients with EGFR T790M mutation-positive non-small-cell lung cancer and a poor performance status. Jpn J Clin Oncol. 2019 Jul 1;49(7):671-675. Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O. Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma. Cancer Sci. 2019 Nov;110(11):3453-3463. Koike K, Beatman EL, Schweitzer KS, Justice MJ, Mikosz AM, Ni K, Clauss MA, Petrache I. Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L558-L566. Baba T, Akai F. S, Kato T, Kusumoto M, Kenmotsu H, Sugiura H, Tominaga J, Oikado K, Sata M, Endo M, Yanagawa N, Sasaki S, Iwasawa T, Saito Y, Fujiwara Y, Ohe Y, Yamazaki N, Sakamoto T, Koshiba T, Kuwano K. Radiologic features of pneumonitis associated with nivolumab in non-small-cell lung cancer and malignant melanoma. Future Oncol., 2019 Jun; 15(16): 1911-1920. Murata K, Inoue Y, Kaiho M, Nakazawa T, Sasaki S, Miyake K, Matsuda S, Tanaka H. Genomic analysis of antibiotic resistance for Acinetobacter baumannii in a critical care center. Acute Med Surg., 2019 Jul; 7(1): e445. Kato M, Yamada T, Kataoka S, Arai Y, Miura K, Ochi Y, Ihara H, Koyama R, Sasaki S, Takahashi K. Prognostic differences among patients with idiopathic interstitial pneumonias with acute exacerbation of varying pathogenesis: a retrospective study. Respir Res. 2019 Dec 18;20(1):287. Sasaki S, Kato M, Nakamura K, Namba Y, Nagashima O, Takahashi K. Management of skin sarcoidosis with minocycline monotherapy. Respirol Case Rep. 2019 Mar 13;7(4):e00413, 2019 Mar eCollection 2019 May.　 Kurokawa K, Asao T, Ko R, Nagaoka T, Suzuki K, Takahashi K. Severe mediastinitis over a month after endobronchial ultrasound-guided transbronchial needle aspiration. Respirol Case Rep. 2019 Apr 9;7(5):e00426. eCollection 2019 Jul Kurokawa K, Hara H, Iwakami S, Genda T, Iwakami N, Miyashita Y, Fujioka M, Sasaki S, Takahashi K. Cholestatic Liver Injury Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma. Intern Med 58(22):3283-3287. Epub 2019 Nov 15. 英文業績（2018） Yasuda M, Harada N, Harada S, Ishimori A, Katsura Y, Itoigawa Y, Matsuno K, Makino F, Ito J, Ono J, Tobino K, Akiba H, Atsuta R, Izuhara K, Takahashi K. Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E. Allergy Asthma Clin Immunol 2018; 14: 72. Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K. Dasatinib Suppresses TGFbeta-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis. Lung 2018;196(5):531-541. Glowacka WK, Jain H, Okura M, Maimaitiming A, Mamatjan Y, Nejad R, Farooq H, Taylor MD, Aldape K, Kongkham P.5-Hydroxymethylcytosine preferentially targets genes upregulated in isocitrate dehydrogenase 1 mutant high-grade glioma. Acta Neuropathol. 2018 Apr;135(4):617-634. Horimoto Y, Tokuda E, Murakami F, Uomori T, Himuro T, Nakai K, Orihata G, Iijima K, Togo S, Shimizu H, Saito M. Analysis of circulating tumour cell and the epithelial mesenchymal transition (EMT) status during eribulin-based treatment in 22 patients with metastatic breast cancer: a pilot study. J Transl Med. 2018 Oct 20;16(1):287. doi: 10.1186/s12967-018-1663-8. Miharu Kato, Yumiko Kanehiro, Kaku Yoshimi, Yuzo Kodama, Mitsuaki Sekiya, Tadashi Sato, Kazuhisa Takahashi, Kuniaki Seyama. COPD assessment test as a possible tool for evaluating health-related quality of life in lymphangioleiomyomatosis Respiratory Investigation, 2018;56；480-488. Miharu Kato, Mitsuaki Sekiya, Yohei Suzuki, Tadashi Sato, Masako Ichikawa, Yuzo Kodama, Kuniaki Seyama, Eri Aikawa-Hirasawa, Kazuhisa Takahashi. Evaluation of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease Using an Accelerometer with Tapestry-Style Display Capability. Juntendo Medical Journal 2018;64: (4): 286-294. Kato M, Sasaki S, Kurokawa K, Nakamura T, Yamada T, Sasano H, Arano N, Komura M, Ihara H, Nagashima O, Shiota S, Takahashi F, Takahashi K. Usual Interstitial Pneumonia Pattern in the Lower Lung Lobes as a Prognostic Factor in Idiopathic Pleuroparenchymal Fibroelastosis. Respiration. 2018 Dec 6:1-10. doi: 10.1159/000494061. Takahashi K, Ueda S, Kobayashi T, Nishiyama A, Fujisawa Y, Sugaya T, Shiota S, Takahashi K, Gohda T, Horikoshi S, Suzuki Y. Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease. Sci Rep. 2018 Dec 18;8(1):17926. doi: 10.1038/s41598-018-36159-9. Mikawa R, Suzuki Y, Baskoro H, Kanayama K, Sugimoto K, Sato T, Sugimoto M. Elimination of p19ARF-expressing cells protects against pulmonary emphysema in mice. Aging Cell, 2018;17(5):e12827. Kobayashi K, Miki Y, Saito R, Adachi K, Seyama K, Okada Y, Sasano H.　Roles of human epidermal growth factor receptor family in pulmonary lymphangioleiomyomatosis　Hum Pathol. 2018 Nov;81:121-130. Oishi H, Watanabe T, Matsuda Y, Noda M, Ejima Y, Saiki Y, Seyama K, Kondo T, Okada Y. Single lung transplantation for lymphangioleiomyomatosis: a single-center experience in Japan. Surg Today. 2018 Oct;48(10):944-950. Callea F, Giovannoni I, Francalanci P, Boldrini R, Faa G, Medicina D, Nobili V, Desmet VJ, Ishak K, Seyama K, Bellacchio E. Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency. Orphanet J Rare Dis. 2018 May 16;13(1):79. Mizobuchi T, Kurihara M, Ebana H, Yamanaka S, Kataoka H, Okamoto S, Kobayashi E, Kumasaka T, Seyama K. A total pleural covering of absorbable cellulose mesh prevents pneumothorax recurrence in patients with Birt-Hogg-Dub? syndrome. Orphanet J Rare Dis. 2018 May 15;13(1):78. Iwabuchi C, Ebana H, Ishiko A, Negishi A, Mizobuchi T, Kumasaka T, Kurihara M, Seyama K. Skin lesions of Birt-Hogg-Dub? syndrome: Clinical and histopathological findings in 31 Japanese patients who presented with pneumothorax and/or multiple lung cysts. J Dermatol Sci. 2018 Jan;89(1):77-84. Mina Y,Norihiro H. Characterization of tenascin-C as a novel biomarker for asthma: Utility of tenascin-C in combination with periostin or immunoglobulin E. Allergy Asthma Clin Immunol. 2018;14:72. Watanabe M, Kenmotsu H, Ko R, Wakuda K, Ono A, Imai H, Taira T, Naito T, Murakami H, Abe M, Endo M, Nakajima T, Koh Y, Takahashi T. Isolation and molecular analysis of circulating tumor cells from lung cancer patients using a microfluidic chip type cell sorter. Cancer Sci. 2018; 109(8): 2539-2548. Kamei R, Yoshimura K, Yoshino S, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Furuya-Kondo T, Oga A, Iizuka N, Suzuki N, Maeda N, Watanabe Y, Matsukuma S, Iida M, Takeda S, Ueno T, Yamamoto N, Fukagawa T, Katai H, Sasaki H, Hazama S, Oka M, Nagano H. Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy. Oncol Lett 2018; 15(1): 747-754. Otani H, Takahashi A, Kato K, Kano N, Watanabe D, Yoshioka R, Fujikawa S, Hongo T, Sugahara R, Hisanaga M, Hirai Y, Mita T, Suzuki K, Takahashi K. Aim and future perspectives of the tropical medicine association of Juntendo University through the activity of the 53rd south east asia research group. Juntendo Medical Journal, 2018; 64(1): 59-63 Ebana H, Mizobuchi T, Kurihara M, Kobayashi E, Haga T, Okamoto S, Takahashi K, Seyama K. Novel clinical scoring system to identify patients with pneumothorax with suspicion for Birt-Hogg-Dub? syndrome. Respirology, 2018; 23(4):414-418 Ebana H, Hayashi T, Mitani K, Kobayashi E, Kumasaka T, Mizobuchi T, Kurihara M, Takahashi F, Takahashi K, Seyama K. Oxidized regenerated cellulose induces pleural thickening in patients with pneumothorax: possible involvement of the mesothelial-mesenchymal transition. Surg Today, 2018; 48(4):462-472 Ihara H, Harada N, Shimada N, Kanamori K, Hayashi T, Uekusa T, Takahashi K. A Case of Malignant Pleural Mesothelioma with Bone Marrow Metastases. Intern Med, 2018; 57(17):2541-2545 Ko R, Shukuya T, Okuma Y, Tateishi K, Imai H, Iwasawa S, Miyauchi E, Fujiwara A, Sugiyama T, Azuma K, Muraki K, Yamasaki M, Tanaka H, Takashima Y, Soda S, Ishimoto O, Koyama N, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group. Prognostic Factors and Efficacy of First-Line Chemotherapy in Patients with Advanced Thymic Carcinoma: A Retrospective Analysis of 286 Patients from NEJ023 Study. Oncologist, 2018; 23(10):1210-1217 Iwakami N, Iwakami SI, Hara M, Sekiya M, Dambara T, Takahashi K. The diagnostic yield using ultrasound-guided needle-aspiration for subpleural primary lung cancer is not affected by the radiological properties of the lesions resulting from computed tomography. Respir Investig. 2018; 56(3):238-242 Watanabe J, Togo S, Sumiyoshi I, Namba Y, Suina K, Mizuno T, Kadoya K, Motomura H, Iwai M, Nagaoka T, Sasaki S, Hayashi T, Uekusa T, Abe K, Urata Y, Sakurai F, Mizuguchi H, Kato S, Takahashi K. Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review. Oncotarget. 2018; 9(35):24000-24013 Homma S, Bando M, Azuma A, Sakamoto S, Sugino K, Ishii Y, Izumi S, Inase N, Inoue Y, Ebina M, Ogura T, Kishi K, Kishaba T, Kido T, Gemma A, Goto Y, Sasaki S, Johkoh T, Suda T, Takahashi K, Takahashi H, Taguchi Y, Date H, Taniguchi H, Nakayama T, Nishioka Y, Hasegawa Y, Hattori N, Fukuoka J, Miyamoto A, Mukae H, Yokoyama A, Yoshino I, Watanabe K; Ministry of Health, Labour and Welfare, the Study Group on Diffuse Pulmonary Disorders, Scientific Research/Research on Intractable Diseases, and Japanese Respiratory Society. Japanese guideline for the treatment of idiopathic pulmonary fibrosis. Respir Investig. 2018; 56(4):268-291 Yamada T, Iwakami SI, Hara SAM, Iwakami N, Nakamura A, Suzuki Y, Sasaki SI, Takahashi K. Disseminated non-tuberculous mycobacterial infection caused by anti-interferon-γ autoantibodies in a patient of very advanced age. Geriatr Gerontol Int. 2018; 18(7):1132-1133 Baskoro H, Sato T, Karasutani K, Suzuki Y, Mitsui A, Arano N, Nurwidya F, Kato M, Takahashi F, Kodama Y, Seyama K, Takahashi K. Regional heterogeneity in response of airway epithelial cells to cigarette smoke. BMC Pulm Med. 2018; 4;18(1):148 Matsuno K, Harada N, Harada S, Takeshige T, Ishimori A, Itoigawa Y, Katsura Y, Kodama Y, Makino F, Ito J, Atsuta R, Akiba H, Takahashi K. Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition. Exp Lung Res. 2018; 44(7):332-343 Komura M, Yagishita S, Nakamura K, Arano N, Takeshige T, Muraki K, Nagashima O, Izumi H, Tomita S, Sasaki S, Takahashi K. A Case of a Pregnant Woman Diagnosed as Having ALK-rearranged Lung Adenocarcinoma.In Vivo. 2018; 32(5):1205-1209 Hara M, Iwakami SI, Sumiyoshi I, Yoshida T, Sasaki S, Takahashi K. Hydrocarbon pneumonitis caused by the inhalation of wood preservative. Respirol Case Rep. 2018; 26;6(9):e00379 Nanjo Y, Newstead MW, Aoyagi T, Zeng X, Takahashi K, Yu FS, Tateda K, Standiford TJ. Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against Murine Legionella pneumophila Pneumonia. Infect Immun. 2018; 19;87(1) Suina K, Tsuchihashi K, Yamasaki J, Kamenori S, Shintani S, Hirata Y, Okazaki S, Sampetrean O, Baba E, Akashi K, Mitsuishi Y, Takahashi F, Takahashi K, Saya H, Nagano O. Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling. Cancer Sci. 2018; 109(12):3874-3882 Ishii M, Suehara Y, Kohsaka S, Hayashi T, Kazuno S, Tanabe Y, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T. Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma. Oncotarget 25;9(101):37509-37519. (2018) Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Murakami T, Watanabe S. Yao T. Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma. Human pathology 78:79-88. (2018) Akaike K, Suehara Y, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Okubo T, Hayashi Y, Takamoch K, Takahashi F, Kaneko K, Saito T. PPP2R1A regulated by PAX3/FOXO3 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. Oncotarget 18;9(38):25206-25215. (2018) Hayashi T, Takamochi K, Yanai Y, Mitani K, Tomita H, Mogushi K, Suehara Y, Takahashi F, Suzuki K, Saito T, Yao T. Non-small cell lung carcinoma with diffuse co-expression of thyroid transcription factor-1 and ΔNp63/p40. Human pathology 78:177-181. (2018) Zhang X, Choi PS, Francis JM, Gao GF, Campbell JD, Ramachandran A, Mitsuishi Y, Ha G, Shih J, Vazquez F, Tsherniak A, Taylor AM, Zhou J, Wu Z, Berger AC, Giannakis M, Hahn WC1, Cherniack AD, Meyerson M. Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor. Cancer Discov. 2018 Jan;8(1):108-125. Hirano T, Ohkouchi S, Tode N, Kobayashi M, Ono M, Satoh T, Mitsuishi Y, Watanabe A, Tabata M, Irokawa T, Ogawa H, Sugiura H, Kikuchi T, Akasaka K, Tazawa R, Inoue Y, Nakata K, Kurosawa H, Ichinose M. Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis. ERJ Open Res. 2018 Mar 23;4(1). pii: 00071-2017. Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018 Sep 18;9(73):33832-33843. Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M. Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival. Nat Commun. 2018 Apr 19;9(1):1561. Yamada T, Amann JM, Tanimoto A, Taniguchi H, Shukuya T, Timmers C, Yano S, Shilo K, Carbone DP. Histone Deacetylase Inhibition Enhances the Antitumor Activity of a MEK Inhibitor in Lung Cancer Cells Harboring RAS Mutations. Mol Cancer Ther. 2018 Jan;17(1):17-25. 英文業績（2017） Kohsaka S, Nagano M, Ueno T, Suehara Y, Hayashi T, Shimada N, Takahashi K, Suzuki K, Takamochi K, Takahashi F, Mano H.A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer.Sci Transl Med. 2017 Nov 15;9(416). Zhang X, Choi PS, Francis JM, Gao GF, Campbell JD, Ramachandran A, Mitsuishi Y, Ha G, Shih J, Vazquez F, Tsherniak A, Taylor AM, Zhou J, Wu Z, Berger AC, Giannakis M, Hahn WC, Cherniack AD, Meyerson M.Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor.Cancer Discov. 2017 Sep 29. pii: CD-17-0532. Hida T, Nokihara H, Kondo M, Kim YH, Azuma K, Seto T, Takiguchi Y, Nishio M, Yoshioka H, Imamura F, Hotta K, Watanabe S, Goto K, Satouchi M, Kozuki T, Shukuya T, Nakagawa K, Mitsudomi T, Yamamoto N, Asakawa T, Asabe R, Tanaka T, Tamura T.Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial.Lancet. 2017 Jul 1;390(10089):29-39. Okamoto S, Togo S, Nagata I, Shimizu K, Koinuma Y, Namba Y, Ito J, Uekusa T, Takahashi K. Lung adenocarcinoma expressing receptor for advanced glycation end-products with primary systemic AL amyloidosis: a case report and literature review. BMC Cancer. 17(1):22. doi: 10.1186/s12885-016-3009-3, 2017 Jan　3.265　 Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu XD, Takahashi K. Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes. Respiratory Research. 18(1):46, 2017 Mar 11 Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono J, Atsuta R, Izuhara K, Takahashi K, Miyake S. Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma. Allergol Int. 66(2): 302-309, 2017 Apr　2.355 Nishino K, Yoshimi K, Shibuya T, Hayashi T, Mitani K, Kobayashi E, Ichikawa M, Asao T, Suzuki Y, Sato T, Shiota S, Kodama Y, Takahashi K, Seyama K. Protein-losing Enteropathy Caused by Intestinal or Colonic Lymphangiectasia Complicated by Sporadic Lymphangioleiomyomatosis: A Report of Two Cases.Intern Med. 56(8):943-948, 2017 Apr 15. Arano N, Morio Y, Futagawa T, Hashizume A, Nagashima O, Sasaki SI, Tominaga S, Takahashi K. Lung metastases from cutaneous adenoid cystic carcinoma 23 years after initial treatment. Respir Med Case Rep. 21:121-123, 2017 Apr 19 Yamada T, Amann JM, Tanimoto A, Taniguchi H, Shukuya T, Timmers C, Yano S, Shilo K, Carbone DP.Histone deacetylase inhibition enhances the antitumor activity of a MEK inhibitor in lung cancer cells harboring RAS mutations.Mol Cancer Ther. 2017 Oct 27. pii: molcanther.0146.2017. Shukuya T, Patel S, Shane-Carson K, He K, Bertino EM, Shilo K, Otterson GA, Carbone DP.Lung Cancer Patients with Germline Mutations Detected by Next-Generation Sequencing and/or Liquid Biopsy.J Thorac Oncol. 2017 Oct 5. pii: S1556-0864(17)32764-8. Otsubo K, Nosaki K, Imamura CK, Ogata H, Fujita A, Sakata S, Hirai F, Toyokawa G, Iwama E, Harada T, Seto T, Takenoyama M, Ozeki T, Mushiroda T, Inada M, Kishimoto J, Tsuchihashi K, Suina K, Nagano O, Saya H, Nakanishi Y, Okamoto I.Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer.Cancer Sci. 2017 Sep;108(9):1843-1849. Ohta T, Mita M, Hishinuma S, Ishii-Nozawa R, Takahashi K, Shoji M. Inhibition of ectopic arginine vasopressin production by phenytoin in the small cell lung cancer cell line Lu-165. Original Research. 2017 April 28. doi: 10.3389/fendo.2017.00094 Ai T, Yuri M, Tabe Y, Kakimoto A, Morishita S, Tsuchiya K, Takamochi K, Kodama Y, Takahashi F, Shigeki M, Horii T, Suzuki K, Takahashi K, Miida T, Ohsaka A.　Comparison of the Analytical Performance Between cobas EGFR Assay and PCR-Clamp Method in the Detection of EGFR Mutations in Japanese Non-Small Cell Lung Cancer Patients. Clin Lab. 63(5):1021-1026, 2017 May 1 Nakamura K, Kato M, Shukuya T, Mori K, Sekimoto Y, Ihara H, Kanemaru R, Ko R, Shibayama R, Tajima K, Koyama R, Shimada N, Nagashima O, Takahashi F, Sasaki S, Takahashi K. Surfactant protein-D predicts prognosis of interstitial lung disease induced by anticancer agents in advanced lung cancer: a case control study.BMC Cancer. 17(1):302.doi: 10.1186/s12885-017-3285-6. 2017 May 2 Togo S, Katagiri N, Namba Y, Tulafu M, Nagahama K, Kadoya K, Takamochi K, Oh S, Suzuki K, Sakurai F, Mizuguchi H, Urata Y, Takahashi K. Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients. Oncotarget. 8(21):34884-34895, 2017 May 23 Okamoto S, Komura M, Terao Y, Kurisaki-Arakawa A, Hayashi T, Saito T, Togo S, Shiokawa A, Mitani K, Kobayashi E, Kumasaka T, Takahashi K, Seyama K. Pneumothorax caused by cystic and nodular lung metastases from a malignant uterine perivascular epithelioid cell tumor (PEComa).Respir Med Case Rep. 22:77-82, 2017 Jun 27 Asao T, Fujiwara Y, Itahashi K, Kitahara S, Goto Y, Horinouchi H, Kanda S, Nokihara H, Yamamoto N, Takahashi K, Ohe Y. Sequential Use of Anaplastic Lymphoma Kinase Inhibitors in Japanese Patients With ALK-Rearranged Non-Small-Cell Lung Cancer: A Retrospective Analysis. Clin Lung Cancer. 18(4): e251-e258, 2017 Jul　 Takaeshige T, Harada N, Sekimoto Y, Kanemaru R, Tsutsumi T, Matsuno K, Shiota S, Masuda A, Gotoh A, Asahina M, Uekusa T, Takahashi K. Pulmonary Intravascular large B-cell lymphoma(IVLBCL) disguised as an Asthma exacerbation in a patient with asthma. Intern Med. 56: 1885-1891, 2017 Kodama Y, Kishimoto Y, Muramatsu Y, Tatebe J, Yamamoto Y, Hirota N, Itoigawa Y, Atsuta R, Koike K, Sato T, Aizawa K, Takahashi K, Morita T, Homma S, Seyama K, Ishigami A. Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease (COPD), asthma-COPD overlap syndrome, and bronchial asthma. Clin Respir J. 2015 Dec 14. doi: 10.1111/crj.12436. [Epub ahead of print] Nurwidya F, Takahashi F, Kato M, Baskoro H, Hidayat M, Wirawan A, Takahashi K. CD44 silencing decreases the expression of stem cell-related factors induced by transforming growth factor β1 and tumor necrosis factor α in lung cancer: Preliminary findings. Bosn J Basic Med Sci. 2017 Apr 24. doi: 10.17305/bjbms.2017.1966. [Epub ahead of print] Sandhu Y, Ando K, Takekawa H, Takagi H, Hirama M, Kido K, Takahashi K.Safety of Bronchoscopy for Patients Undergoing Hemodialysis.Respir Investig. 2017 Mar;55(2):173-175. Yoshikawa H, Fujii M, Iwakami SI, Takeda I, Hayakawa D, Takahashi K.Chylothorax ascribed to chronic heart failure in a woman of very advanced years.Geriatr Gerontol Int. 2017 Jul;17(7):1133-1135. Suzuki Y, Sato T, Sugimoto M, Baskoro H, Karasutani K, Mitsui A, Nurwidya F, Arano N, Kodama Y, Hirano SI, Ishigami A, Seyama K, Takahashi K.Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.Biochem Biophys Res Commun. 2017 Oct 7;492(1):74-81. Honma Y, Togo S, Shimizu K, Tulafu M, Hayashi T, Uekusa T, Tominaga S, Kido K, Fujimoto Y, Nanba Y, Takamochi K, Oh S, Suzuki K, Takahashi K.Expression of thymidylate synthase predicts clinical outcomes of S-1-based chemotherapy in squamous cell lung cancer.Oncol Lett. 2017 Sep;14(3):3319-3326. Jotatsu T, Yagishita S, Tajima K, Takahashi F, Mogushi K, Hidayat M, Wirawan A, Ko R, Kanemaru R, Shimada N, Mitani K, Saito T, Takamochi K, Suzuki K, Kohsaka S, Kojima S, Mukae H, Yatera K, Takahashi K.LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer.Biochem Biophys Rep. 2016 Dec 1;9:86-94. Ebana H, Mizobuchi T, Kurihara M, Kobayashi E, Haga T, Okamoto S, Takahashi K, Seyama K.Novel clinical scoring system to identify patients with pneumothorax with suspicion for Birt-Hogg-Dubé syndrome.Respirology. 2017 Sep 27. doi: 10.1111/resp.13191. [Epub ahead of print] Ebana H, Hayashi T, Mitani K, Kobayashi E, Kumasaka T, Mizobuchi T, Kurihara M, Takahashi F, Takahashi K, Seyama K.Oxidized regenerated cellulose induces pleural thickening in patients with pneumothorax: possible involvement of the mesothelial-mesenchymal transition.Surg Today. 2017 Oct 12. doi: 10.1007/s00595-017-1597-4. [Epub ahead of print] Nakamura K, Kato M, Miyashita Y, Nagashima O, Sasaki S, Tominaga S, Takahashi K.Development of interstitial pneumonia during treatment with eribulin: a case report.BMC Res Notes. 2017 Nov 6;10(1):557. Tobino K, Hirai T, Johkoh T, Fujimoto K, Kawaguchi A, Tomiyama N, Takahashi K, Seyama K.Difference of the progression of pulmonary cysts assessed by computed tomography among COPD, lymphangioleiomyomatosis, and Birt-Hogg-Dubé syndrome.PLoS One. 2017 Dec 8;12(12):e0188771. Takamochi K, Takahashi F, Suehara Y, Kitano S, Sato E, Kohsaka S, Hayashi T, Mano H, Suzuki K.DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel Lung Cancer.Lung Cancer 110:26-31. (2017) Iwabuchi C, Ebana H, Ishiko A, Negishi A, Mizobuchi T, Kumasaka T, Kurihara M, Seyama K.Skin lesions of Birt-Hogg-Dubé syndrome: Clinical and histopathological findings in 31 Japanese patients who presented with pneumothorax and/or multiple lung cysts.J Dermatol Sci. 2017 Nov 2. pii: S0923-1811(17)30462-0. Gupta N, Finlay GA, Kotloff RM, Strange C, Wilson KC, Young LR, Taveira-DaSilva AM, Johnson SR, Cottin V, Sahn SA, Ryu JH, Seyama K, Inoue Y, Downey GP, Han MK, Colby TV, Wikenheiser-Brokamp KA, Meyer CA, Smith K, Moss J, McCormack FX; ATS Assembly on Clinical Problems.Lymphangioleiomyomatosis Diagnosis and Management: High-Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline.Am J Respir Crit Care Med. 2017 Nov 15;196(10):1337-1348. Kitamura N, Seyama K, Inoue Y, Nagai K, Suzuki M, Moriyama H, Takada T, Tazawa R, Hirai T, Mishima M, Hayashida M, Hirose M, Arai T, Sugimoto C, Hattori N, Watanabe K, Tamada T, Akazawa K, Tanaka T, Nakata K.Risk factors for stomatitis in patients with lymphangioleiomyomatosis during treatment with sirolimus: A multicenter investigator-initiated prospective study.Pharmacoepidemiol Drug Saf. 2017 Oct;26(10):1182-1189. Onodera K, Sugiura H, Yamada M, Koarai A, Fujino N, Yanagisawa S, Tanaka R, Numakura T, Togo S, Sato K, Kyogoku Y, Hashimoto Y, Okazaki T, Tamada T, Kobayashi S, Yanai M, Miura M, Hoshikawa Y, Okada Y, Suzuki S, Ichinose M.Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease.Thorax. 2017 Oct;72(10):893-904. Saito M, Fujiwara Y, Asao T, Honda T, Shimada Y, Kanai Y, Tsuta K, Kono K, Watanabe S, Ohe Y, Kohno T.The genomic and epigenomic landscape in thymic carcinoma.Carcinogenesis. 2017 Oct 26;38(11):1084-1091. Konagai A, Yoshimura K, Hazama S, Yamamoto N, Aoki K, Ueno T, Fujioka M, Iijima H, Kato M, Uchida M, Wada T, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Kamei R, Takeda S, Yamamoto S, Yoshino S, Oka M, Nagano H.Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.Anticancer Res. 2017 Aug;37(8):4093-4101. Nakamichi S, Horinouchi H, Asao T, Goto Y, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Ito Y, Watanabe SI, Ohe Y.Comparison of Radiotherapy and Chemoradiotherapy for Locoregional Recurrence of Non-small-cell Lung Cancer Developing After Surgery.Clin Lung Cancer. 2017 Nov;18(6):e441-e448. Okuma HS, Horinouchi H, Kitahara S, Asao T, Sunami K, Goto Y, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Ohe Y.Comparison of Amrubicin and Weekly Cisplatin/Etoposide/Irinotecan in Patients With Relapsed Small-cell Lung Cancer.Clin Lung Cancer. 2017 Mar;18(2):234-240. Shitara K, Doi T, Nagano O, Fukutani M, Hasegawa H, Nomura S, Sato A, Kuwata T, Asai K, Einaga Y, Tsuchihashi K, Suina K, Maeda Y, Saya H, Ohtsu A.Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).Gastric Cancer. 2017 Nov;20(6):1004-1009. Ikari J, Nelson AJ, Obaid J, Giron-Martinez A, Ikari K, Makino F, Iwasawa S, Gunji Y, Farid M, Wang X, Basma H, Demeo D, Feghali-Bostwick C, Holz O, Rabe K, Liu X, Rennard SI.Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease.PLoS One. 2017 Sep 7;12(9):e0184039. 英文業績（2016） Ando K, Okada Y, Akiba M, Kondo T, Kawamura T, Okumura M, Chen F, Date H, Shiraishi T, Iwasaki A, Yamasaki N, Nagayasu T, Chida M, Inoue Y, Hirai T, Seyama K, Mishima M and the Respiratory Failure Research Group of the Japanese Ministry of Health, Labour, and Welfare.Lung transplantation for lymphangioleiomyomatosis in Japan.PLos One 2016; 11(1): e0146749. Fujita A, Ando K, Kobayashi E, Mitani K, Okudera K, Nakashima M, Miyatake S, Tsurusaki Y, Saitsu H, Seyama K, Miyake N, Matsumoto N.Detection of low-prevalence somatic TSC2 mutations in sporadic pulmonary lymphangioleiomyomatosis tissues by deep sequencing.Hum Genet. 2016,135(1):61-8. Gunji-Niitsu Y, Kumasaka T, Kitamura S, Hoshika Y, Hayashi T, Tokuda H, Morita R, Kobayashi E, Mitani K, Kikkawa M, Takahashi K, Seyama K.Benign clear cell sugar tumor of the lung in a patient with Birt-Hogg-Dub? syndrome: a case report.BMC Med Genet. 2016,17(1):85. Jotatsu, T., Yagishita, S., Tajima, K., Takahashi, F., Mogushi, K., Hidayat, M., Wirawan, A., Ko, R., Kanemaru, R., Shimada, N., Mitani, K., Saito, T., Takamochi, K., Suzuki, K., Kohsaka, S., Kojima, S., Mukae, H., Yatera, K., and Takahashi, K. LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer.Biochemical and biophysical research communications. 2016;473(1):125-132.Kato M, Sasaki S, Sekimoto Y, Arano N, Jo H, Suina K, Kuriyama S, Muraki K, Nagashima O, Yoshioka Y, Tominaga S, Takahashi K.Loxoprofen-induced interstitial pneumonia: a case report.J Med Case Rep. 2016,10(1):128. Ko R, Kenmotsu H, Serizawa M, Koh Y, Wakuda K, Ono A, Taira T, Naito T, Murakami H, Isaka M, Endo M, Nakajima T, Ohde Y, Yamamoto N, Takahashi K, Takahashi TFrequency of EGFR T790M mutatoin and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tryosine kinase inhibitors in Japanese patientsBMC cancer, 2016; 16(1): 864 Kobayashi I, Takahashi F, Nurwydia F, Nara T, Hashimoto M, Murakami A, Yagishita S, Tajima K, Hidayat M, Shimada N, Suina K, Yoshioka Y, Sasaki S, Moriyama M, Moriyama H, Takahashi K.Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells.Biochem Biophys Res Commun. 2016,22;473(1):125-32. Koyama R, Takahashi K.Non-Small-Cell lung cancer treatment: cytotoxic chemotherapy, molecular targeted therapy, and immunotherapy.Juntendo Medical Journal,2016, 62(1): 7-12. Kato M, Morio Y, Matsunaga T, Shiraishi A, Uekusa T, Takahashi K.Bronchial-pulmonary arterial fistula with primary racemose hemangioma.Respirol Case Rep. 2016,4(2):e00148. Nurwidya F, Takahashi F, Takahashi K. Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation. J Nat Sci Biol Med. 2016,7(2):119-23. Sekimoto Y, Kato M, Shukuya T, Koyama R, Nagaoka T, Takahashi K.Bevacizumab-induced chronic interstitial pneumonia during maintenance therapy in non-small cell lung cancer.Respirol Case Rep. 2016 ,4(2):e00151. Ebana H, Otsuji M, Mizobuchi T, Kurihara M, Takahashi K, Seyama K.Pleural Covering Application for Recurrent Pneumothorax in a Patient with Birt-Hogg-Dub? Syndrome.Ann Thorac Cardiovasc Surg.2016, 22(3):189-92. Fukui M, Takamochi K, Matsunaga T, Oh S, Ando K, Suzuki K, Arakawa A, Uekusa T, Suzuki K.Risk of the preoperative underestimation of tumour size of lung cancer in patients Hayashida M, Yasuo M, Hanaoka M, Seyama K, Inoue Y, Tatsumi K, Mishima M; Respiratory Failure Research Group of the Ministry of Health, Labour, and Welfare, Japan.Reductions in pulmonary function detected in patients with lymphangioleiomyomatosis: An analysis of the Japanese National Research Project on Intractable Diseases database.Respir Investig. 2016,54(3):193-200. Ebana H, Otsuji M, Mizobuchi T, Kurihara M, Takahashi K, Seyama K.Pleural Covering Application for Recurrent Pneumothorax in a Patient with Birt-Hogg-Dub? Syndrome.Ann Thorac Cardiovasc Surg. 2016,22(3):189-92. Sakurai F, Narii N, Tomita K, Togo S, Takahashi K, Machitani M, Tachibana M, Ouchi M, Katagiri N, Urata Y, Fujiwara T, Mizuguchi H.Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus.Mol Ther Methods Clin Dev. 2016,3:16001. Sawada T, Watanabe M, Fujimura Y, Yagishita S, Shimoyama T, Maeda Y, Kanda S, Yunokawa M, Tamura K, Tamura T, Minami H, Koh Y, Koizumi F.Sensitive cytometry based system for enumeration, capture and analysis of gene mutations of circulating tumor cells.Cancer Sci. 2016,107(3):307-14. Seyama K, Hirai T, Mishima M, Tatsumi K, Nishimura M; Respiratory Failure Research Group of the Japanese Ministry of Health, Labour, and Welfare.A nationwide epidemiological survey of alpha1-antitrypsin deficiency in Japan.Respir Investig. 2016,54(3):201-6. Yamada K, Ichiki M, Takahashi K, Hisamatsu Y, Takeoka H, Azuma K, Shukuya T, Nishikawa K, Tokito T, Ishii H, Hoshino T.A multicenter phase II trial of S-1 combined with bevacizumab after platinum-based chemotherapy in patients with advanced non-squamous non-small cell lung cancerCancer Chemother Pharmacol. 2016,78(3):501-7. Yoshimi K, Oh S, Suzuki K, Kodama Y, Sekiya M, Seyama K, Fukuchi Y.Impact of Airflow Limitation on Comorbidities and Postoperative Complications in Patients Undergoing Thoracic Surgery: A Retrospective ObservationaAnn Thorac Cardiovasc Surg. 2016,22(3):146-52. Hoshika Y, Takahashi F, Togo S, Hashimoto M, Nara T, Kobayashi T, Nurwidya F, Kataoka H, Kurihara M, Kobayashi E, Ebana H, Kikkawa M, Ando K, Nishino K, Hino O, Takahashi K, Seyama K.Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dub? syndrome.Physiol Rep. 2016,4(21). pii: e13025. Kato M, Sasaki S, Izumi H, Uekusa T, Tominaga S, Takahashi K.Development of diffuse alveolar damage after initiation of Nijutsuto.Respirol Case Rep. 2016,25;4(6):e00195. Ando K, Nakashita T, Kaneko N, Takahashi K, Motojima S.Associations between peripheral blood eosinophil counts in patients with systemic sclerosis and disease severity.Springer Plus 2016,5: 1401. Nakashita T, Ando K, Takahashi K, Motojima S.Possible effect of abatacept on the progression of interstitial lung disease in rheumatoid arthritis patients.Respiratory Investigation. 2016,54(5): 376-379. Comaills V, Kabeche L, Morris R, Buisson R, Yu M, Madden MW, LiCausi JA, Boukhali M, Tajima K, Pan S, Aceto N, Sil S, Zheng Y, Sundaresan T, Yae T, Jordan NV, Miyamoto DT, Ting DT, Ramaswamy S, Haas W, Zou L, Haber DA, Maheswaran SGenomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal TransitionCell Rep. 2016,6;17(10):2632-2647 McCormack FX, Gupta N, Finlay GR, Young LR, Taveira-DaSilva AM, Glasgow CG, Steagall WK, Johnson SR, Sahn SA, Ryu JH, Strange C, Seyama K, Sullivan EJ, Kotloff RM, Downey GP, Chapman JT, Han MK, D'Armiento JM, Inoue Y, Henske EP, Bissler JJ, Colby TV, Kinder BW, Wikenheiser-Brokamp KA, Brown KK, Cordier JF, Meyer C, Cottin V, Brozek JL, Smith K, Wilson KC, Moss J; ATS/JRS Committee on LymphangioleiomyomatosisOfficial American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines:Lymphangioleiomyomatosis Diagnosis and Management.Am J Respir Crit Care Med. 2016,15;194(6):748-61 Shigematsu, M., T. Koga, A. Ishimori, K. Saeki, Y. Ishii, Y. Taketomi, M. Ohba, A. Jo-Watanabe, T. Okuno, N. Harada, T. Harayama, H. Shindou, J. D. Li, M. Murakami, S. Hoka, and T. Yokomizo.Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury. Sci Rep, 2016; 6: 34560. Shigeru TominagaClinic-based lung cancer screening in UrayasuJuntendo Medical Journal 2016;62(6):455-459. Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono J, Atsuta R, Izuhara K, Takahashi K, Miyake S.Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma.Allergol Int. 2016 Aug 26. Hishida T, Miyaoka E, Yokoi K, Tsuboi M, Asamura H, Kiura K, Takahashi K, Dosaka-Akita H, Kobayashi H, Date H, Tada H, Okumura M, Yoshino I.Lobe-Specific Nodal Dissection for Clinical Stage I and II NSCLC: Japanese Multi-Institutional Retrospective Study Using a Propensity Score Analysis.J Thorac Oncol. 2016,11(9):1529-37. Jiang L, Konishi H, Nurwidya F, Takahashi F, Ebinuma H, Fujimura K, Takasu K, Jiang M, Bujo H, Daida H.Deletion of smooth muscle cell migration regulator LR11 attenuates the hypoxia- induced pulmonary arterial remodeling with medial thickening in mice.Arterioscler Thromb Vasc Biol 2016,36(9):1972-9. Kurihara M, Mizobuchi T, Kataoka H, Sato T, Kumasaka T, Ebana H, Yamanaka S, Endo R, Miyahashira S, Shinya N, Seyama K.A Total Pleural Covering for Lymphangioleiomyomatosis Prevents Pneumothorax Recurrence.PLoS One. 2016,22;11(9):e0163637 Ando K, Fujino N, Mitani K, Ota C, Okada Y, Kondo T, Mizobuchi T, Kurihara M, Suzuki K, Hoshika Y, Ebana H, Kobayashi E, Takahashi K, Kubo H, Seyama K.Isolation of individual cellular components from lung tissues of patients with lymphangioleiomyomatosis.Am J Physiol Lung Cell Mol Physiol. 2016;310(10):L899-908. Kato M, Shukuya T, Mori K, Kanemaru R, Honma Y, Nanjo Y, Muraki K, Shibayama R, Koyama R, Shimada N, Takahashi F, Takahashi K.Cerebral infarction in advanced non-small cell lung cancer: a case control study.BMC Cancer. 2016,10;16:203. Okuma HS, Horinouchi H, Kitahara S, Asao T, Sunami K, Goto Y, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Ohe Y.Comparison of amrubicin and weekly cisplatin/etoposide/irinotecan in patients with relapsed small-cell lung cancer.Clin Lung Cancer 2016 Oct 25. Yuuki Sandhu, Katsutoshi Ando, Hidenori Takekawa, Haruhi Takagi, Michihiro Hirama, Kenji Kido, Kazuhisa TakahashiSafety of Bronchoscopy for Patients Undergoing HemodialysisRespiratory Investigation, 2016; 10. 007 Shukuya T, Mori K, Amann JM, Bertino EM, Otterson GA, Shields PG, Morita S, Carbone DP.Relationship between Overall Survival and Response or Progression-Free Survival in Advanced Non-Small Cell Lung Cancer Patients Treated with Anti-PD-1/PD-L1 Antibodies.J Thorac Oncol. 2016,11(11):1927-1939. Takada T, Mikami A, Kitamura N, Seyama K, Inoue Y, Nagai K, Suzuki M, Moriyama H, Akasaka K, Tazawa R, Hirai T, Mishima M, Hayashida M, Hirose M, Sugimoto C, Arai T, Hattori N, Watanabe K, Tamada T, Yoshizawa H, Akazawa K, Tanaka T, Yagi K, Young LR, McCormack FX, Nakata K.Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis.Ann Am Thorac Soc. 2016,13(11):1912-1922. Asao T, Fujiwara Y, Itahashi K, Kitahara S, Goto Y, Horinouchi H, Kanda S, Nokihara H, Yamamoto N, Ohe Y.Sequential use of anaplastic lymphoma kinase inhibitors in Japanese patients with ALK-rearranged non-small-cell lung cancer Sequential use of anaplastic lymphoma kinase inhibitors in Japanese patients with ALK-rearranged non-small-cell lung cancer: A retrospective analysis.Clin Lung Cancer 2016 Dec 7 Hashimoto M, Asai A, Kawagishi H, Mikawa R, Iwashita Y, Kanayama K, Sugimoto K, Sato T, Maruyama M, Sugimoto M.Elimination of p19ARF-expressing cells enhances pulmonary function in miceJCI Insight, 2016;1(12):e87732 Yamane Y, Shiono A, Ishii Y, Isobe K, Miyauchi E, Kishi K, Nishino M, Sugawara S, Ko R, Koyama N, Yabuki Y, Kobayashi KTreatment and outcomes of advanced/recurrent non-small cell lung cancer harboring the EGFR T790M mutation: a retrospective observational study of 141 patients in JapanJpn J Clin Oncol, 2016,46(12): 1135-1142 Atsuta R, To Y, Sakamoto S, Mukai I, Kobayashi A, Kinoshita A, Takahashi K.Assessing usability of the Adherence Starts with Knowledge 20 (ASK-20) questionnaire for Japanese adults with bronchial asthma receiving inhaled corticosteroids long term.Allergol Int. pii: S1323-8930(16)30150-2, 2016. Hayashi T, Kumasaka T, Mitani K, Okada Y, Kondo T, Date H, Chen F, Oto T, Miyoshi S, Shiraishi T, Iwasaki A, Hara K, Saito T, Ando K, Kobayashi E, Gunji-Niitsu Y, Kunogi M, Takahashi K, Yao T, Seyama K.Bronchial involvement in advanced stage lymphangioleiomyomatosis: histopathologic and molecular analyses.Hum Pathol. 2016,50:34-42. Katsuya Y, Horinouchi H, Asao T, Kitahara S, Goto Y, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Watanabe S, Tsuta K, Ohe Y.Expression of programmed death 1 (PD-1) and its ligand (PD-L1) in thymic epithelial tumors: Impact on treatment efficacy and alteration in expression after chemotherapy.Lung Cancer 2016; 99: 4-10. Kentaro Suina , Takehito Shukuya, , Ryo Koyama , Tetsuhiko Asao , Yuichiro Honma , Motoyasu Kato , Keiko Muraki , Rina Shibayama , Naoko Shimada , Fumiyuki Takahashi , Shoko Sakuraba , Kazuhisa TakahashiRisk factors for serious adverse events due to cytotoxic chemotherapy for advanced non-small cell lung cancer.Cancer Treatment and Research Communications 2016;19:106 Kodama Y, Kishimoto Y, Muramatsu Y, Tatebe J, Yamamoto Y, Hirota N, Itoigawa Y, Atsuta R, Koike K, Sato T, Aizawa K, Takahashi K, Morita T, Homma S, Seyama K, Ishigami AAntioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease (COPD), asthma-COPD overlap syndrome, and bronchial asthma.The Clinical Respiratory Journal2016　ISSN 1752-6981 英文業績（2015） Satomi Shiota, Masako Ichikawa, Kazuhiro Suzuki, Yoshinosuke Fukuchi, Kazuhisa Takahashi.Practical surrogate marker of pulmonary dysanapsis by simple spirometry.BMC Fam Pract. 2015 26;16(1):41. Wakuda K, Kenmotsu H, Naito T, Akamatsu H, Ono A, Shukuya T, Nakamura Y, Tsuya A, Murakami H, Takahashi T, Endo M, Nakajima T, Yamamoto NEfficacy of Rechallenge Chemotherapy in Patients With Sensitive Relapsed Small CellAm J Clin Oncol .2015 38(1): 28-32. Yagishita S, Horinouchi H, Katsui Taniyama T, Nakamichi S, Kitazono S, Mizugaki H, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Sumi M, Shiraishi K, Kohno T, Furuta K, Tsuta K, Tamura T.Epidermal growth factor receptor mutation is associated with longer local control after definitivechemoradiotherapy in patients with stage III nonsquamous non-small-cell lung cancer.Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):140-8. Kenmotsu H, Naito T, Mori K, Ko R, Ono A, Wakuda K, Imai H, Taira T, Murakami H, Endo M, Takahashi TEffect of platinum-based chemotherapy for non-small cell lung cancer patients with interstitial lung cancerCancer Chemother Pharmacol, 2015. 75(3): 521-6 Miura S, Kaira K, Kaira R, Akamatsu H, Ono A, Shukuya T, Tsuya A, Nakamura Y, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Yamamoto NThe efficacy of amrubicin on central nervous system metastases originating from small-cell lung cancer: a case series of eight patients.Invest New Drugs.2015 33(3): 755-60. Fujita Y, Yagishita S, Hagiwara K, Yoshioka Y, Kosaka N, Takeshita F, Fujiwara T, Tsuta K, NokiharaH, Tamura T, Asamura H, Kawaishi M, Kuwano K, Ochiya T.The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer.Mol Ther. 2015 Apr;23(4):717-27. Gupta N, Meraj R, Tanase D, James LE, Seyama K, Lynch DA, Akira M, Meyer CA, Ruoss SJ, Burger CD, Young LR, Almoosa KF, Veeraraghavan S, Barker AF, Lee AS, Dilling DF, Inoue Y, Cudzilo CJ, Zafar MA, McCormack FX.Accuracy of chest high-resolution computed tomography in diagnosing diffuse cystic lung diseases.Eur Respir J. 2015 Oct;46(4):1196-9. Horinouchi H, Yamamoto N, Fujiwara Y, Sekine I, Nokihara H, Kubota K, Kanda S, Yagishita S, Wakui H, Kitazono S, Mizugaki H, Tokudome T, Tamura T.Phase I study of ipilimumab in phased combination with paclitaxel and carboplatin in Japanese patients with non-small-cell lung cancer.Invest New Drugs. 2015 Aug;33(4):881-9. Ichikawa M, Kodama Y, Yoshimi K, Shiota S, Kotajima M, Nakajyo M, Seyama K, Fukuchi Y, Takahashi K.Effects of transdermal tulobuterol on dyspnea and respiratory function during exercise in patients with chronic obstructive pulmonary disease.J Thorac Dis. 2015 Apr;7(4):687-96. Ko R, Kenmotsu H, Hisamatsu Y, Akamatsu H, Omori S, Nakashima K, Oyakawa T, Wakuda K, Shukuya T, Ono A, Imai H, Taira T, Naito T, Murakami H, Mori K, Endo M, Ohde Y, Takahashi K, Takahashi T.The effect of gefitinib in patients with postoperative recurrent non-small cell lung cancer harboring mutations of the epidermal growth factor receptor.Int J Clin Oncol. 2015 20(4):668-73. Kumasaka T, Hoshika Y, Kobayashi E, Mitani K, Okura MK, Hong YK, Takahashi K, Seyama K.A Model of Lymphangioleiomyomatosis in a Three-Dimensional Culture System.Lymphat Res Biol. 2015 Dec; 13(4):248-52. Shukuya T, Ko R, Mori K, Kato M, Yagishita S, Kanemaru R, Honma Y, Shibayama R, Koyama R, Shimada N, Takahashi K.Prognostic factors in non-small cell lung cancer patients who are recommended to receive single-agent chemotherapy (docetaxel or pemetrexed) as a second- or third-line chemotherapy: in the era of oncogenic drivers and molecular-targeted agents.Cancer Chemother Pharmacol. 2015 Oct; 76(4):771-6. Shukuya T, Yamanaka T, Seto T, Daga H, Goto K, Saka H, Sugawara S, Takahashi T, Yokota S, Kaneda H, Kawaguchi T, Nagase S, Oguri T, Iwamoto Y, Nishimura T, Hattori Y, Nakagawa K, Nakanishi Y, Yamamoto N.Nedaplatin plus docetaxel versus cisplatin plus docetaxel for advanced or relapsed squamous cell carcinoma of the lung (WJOG5208L): a randomised phase 3 study.Lancet Oncol 2015; 16(16): 1630-8. Hishida T, Tsuboi M, Shukuya T, Takamochi K, Sakurai H, Yoh K, Ohashi Y, Kunitoh H.Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6).Jpn J Clin Oncol.2015 45(5): 499-501. Sekiya M, Yoshimi K, Muraki K, Iwakami S, Togo S, Tamaki S, Dambara T, Takahashi K.Do respiratory comorbidities limit the diagnostic usefulness of ultrasound-guided needle aspiration for subpleural lesions?Respir Investig. 2015 May;53(3):98-103. Ando K, Kuraishi H, Nagaoka T, Tsutsumi T, Hoshika Y, Kimura T, Ienaga H, Morio Y, Takahashi K.Potential role of CT metrics in chronic obstructive pulmonary disease with pulmonary hypertensionLung 2015; 193(6): 911-918. Fujita Y, Yagishita S, Takeshita F, Yamamoto Y, Kuwano K, Ochiya T.Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.Oncotarget. 2015 Feb 20;6(5):3335-45. Iwakami S, Fujii M, Tsutsumi T, Sekimoto Y, Jo H, Hara M, Iwakami N, Takahashi K.Autoimmune pulmonary alveolar proteinosis with primary lung cancer in a patient of very advanced years.Geriatr Gerontol Int.2015 15: 666-667. Tajima K, Yae T, Javaid S, Tam O, Comaills V, Wittner B, Morris R, Liu M, Engstrom A, Takahashi F, Black J, Ramaswamy S, Shioda T, Hammell M, Haber DA, Whetstine JR, Maheswaran S.SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes.Nature Commun 2015 23;6:8257. Yagishita S, Fujita Y, Kitazono S, Ko R, Nakadate Y, Sawada T, Kitamura Y, Shimoyama T, Maeda Y,Takahashi F, Takahashi K, Tamura T, Koizumi F.Chemotherapy-Regulated microRNA-125-HER2 Pathway as a Novel Therapeutic Target for Trastuzumab-Mediated Cellular Cytotoxicity in Small Cell Lung Cancer.Mol Cancer Ther. 2015 Jun;14(6):1414-23. Iida T, Shiba M, Yohino I, Miyaoka E, Asamura H, Date H, Okumura M, Tada H, Nakanishi Y, Dosaka H, Kobayashi H, Takahashi K, Inoue M, Yokoi K.Surgical intervention for non?small-cell lung cancer patients with pleural carcinomatosis results from the Japanese lung cancer registry in 2004.Journal of Thoracic Oncology.2015 10(7):1076-1082. Itoigawa Y, Harada N, Harada S, Katsura Y, Makino F, Ito J, Nurwidya F, Kato M, Takahashi F, Atsuta R, Takahashi K.TWEAK enhances TGF-beta-induced epithelial-mesenchymal transition in BEAS-2B human bronchial epithelial cells.Respir Research 2015 8;16:48. Sugano K, Okuyama T, Iida S, Komatsu H, Ishida T, Kusumoto S, Uchida M, Nakaguchi T, Kubota Y, Ito Y, Takahashi K, Akechi T.Medical decision-making incapacity among newly diagnosed older patients with hematological malignancy receiving first line chemotherapy: A cross-sectional study of patients and physiciansPLoS One. 2015 Aug 21;10(8) Ebana H, Otsuji M, Mizobuchi T, Kurihara M, Takahashi K, Seyama K.Pleural Covering Application for Recurrent Pneumothorax in a Patient with Birt-Hogg-Dub? Syndrome.Ann Thorac Cardiovasc Surg. 2015 Sep 11 Fujimoto Y, Togo S, Tulafu M, Shimizu K, Hayashi T, Uekusa T, Honma Y, Namba Y, Takamochi K, Oh S, Suzuki K, Takahashi K.Variation in the expression levels of predictive chemotherapy biomarkers in histological subtypes of lung adenocarcinoma: an immunohistochemical study of tissue samples.Int J Clin Exp Pathol. 2015 Sep 1;8(9):10523-33. Harada S, Harada N, Itoigawa Y, Katsura Y, Kasuga F, Ishimori A, Makino F, Ito J, Atsuta R, Takahashi K.Evaluation of switching low dose inhaled corticosteroid to pranlukast for step-down therapy in well-controlled patients with mild persistent asthma.J Asthma. 2015 Sep 1:1-27. Wakida K, Watanabe Y, Kumasaka T, Seyama K, Mitani K, Hiraki T, Kamimura G, Nagata T, Nakamura Y, Sato M.Lymphangioleiomyomatosis in a Male.Ann Thorac Surg. 2015 Sep;100(3):1105-7. Yagishita S, Horinouchi H, Sunami KS, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Sumi M,Shiraishi K, Kohno T, Furuta K, Tsuta K, Tamura T, Ohe Y.Impact of KRAS mutation on response and outcome of patients with stage III non-squamous non-small cell lung cancer.Cancer Sci. 2015 Oct;106(10):1402-7. Adachi K, Miki Y, Saito R, Hata S, Yamauchi M, Mikami Y, Okada Y, Seyama K, Kondo T, Sasano H.Intracrine steroid production and mammalian target of rapamycin pathways in pulmonary lymphangioleiomyomatosis.Hum Pathol. 2015 Nov;46(11):1685-93. Asao T, Nokihara H, Yoh K, Niho S, Goto K, Ohmatsu H, Kubota K, Yamamoto N, Sekine I, Kunitoh H, Fujiwara Y, Ohe Y.Phase II study of amrubicin at a dose of 45 mg/m2 in patients with previously treated small-cell lung cancer.Jpn J Clin Oncol 2015; 45: 941-946. Mizugaki H, Yamamoto N, Nokihara H, Fujiwara Y, Horinouchi H, Kanda S, Kitazono S, Yagishita S, Xiong H, Qian J, Hashiba H, Shepherd SP, Giranda V, Tamura T.A phase 1 study evaluating the pharmacokinetics and preliminary efficacy of veliparib (ABT-888) in combination with carboplatin/paclitaxel in Japanese subjects with non-small cell lung cancer (NSCLC).Cancer Chemother Pharmacol. 2015 Nov;76(5):1063-72. Kamachi, F., T. Isshiki, N. Harada, H. Akiba, and S. Miyake.ICOS promotes group 2 innate lymphoid cell activation in lungs.Biochem Biophys Res Commun 2015 463: 739-745. 英文業績（2014） Nurwidya F, Takahashi F, Kobayashi I, Murakami A, Kato M, Minakata K, Nara T, Hashimoto M, Yagishita Y, Baskoro H, Hidayat M, Shimada N, Takahashi K.Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancerBiochem Biophys Res Commun. 12;455(3-4):332-8. (2014) Murakami A, Takahashi F, Nurwidya F, Kobayashi I, Minakata K, Hashimito M, Nara T, Kato M, Tajima K, Shimada N,Iwakami S, Moriyama M, Moriyama H, Koizumi F, Takahashi K.Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.PLoS One. Jan; 9(1): e86459, 2014　3.730 Koike K, Ishigami A, Sato Y, Hirai T, Yuan Y, Kobayashi E, Tobino K, Sato T, Sekiya M, Takahashi K, Fukuchi Y, Maruyama N, Seyama K.Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration.Am J Respir Cell Mol Biol. 50(2):347-57. (2014) Shiota S, Inoue Y, Takekawa H, Kotajima M, Nakajyo M, Usui C, Yoshioka Y, Koga T, Takahashi K.Effect of continuous positive airway pressure on regional cerebral blood flow during wakefulness in obstructive sleep apnea.Sleep Breath. 18(2):289-95. (2014) Iwakami S, Ihara H, Fujii M, Takahashi K.A pulmonary nodule exhibiting temporary spontaneous regression.Intern Med. 53(4): 337-8, 2014　0.973 Kuriyama S, Morio Y, Toba M, Nagaoka T, Takahashi F, Iwakami S, Seyama K, Takahashi K.Genistein attenuates hypoxic pulmonary hypertension via enhanced nitric oxide signaling and the erythropoietin system.Am J Physiol Lung Cell Mol Physiol. Jun 1;306(11):L996-L1005, 2014 Fujii M, Iwakami S, Itoigawa Y, Takahashi K.Interesting radiological images of a tuberculous abscess.Intern Med. 53(10):1097-8, 2014 Suina K, Hayashi T, Mitani K, Suzuki K, Takahashi K, Seyama K.What's the role of sirolimus on the treatment of lymphangioleiomyomatosis (LAM)?: Merely tuning up of LAM-associated dysfunctional lymphatic vessels rather than cytoreduction?Respir Investig. Jul;52(4):274-6, 2014 Ando K, Takahashi F, Kato M, Kaneko N, Doi T, Ohe Y, Koizui F, Nishio K, Takahashi K. Tocilizumab, a proposed therapy for the cachexia of interleukin6-expressing lung cancer. PLoS One. Jul;9(7): e102436, 2014  3.730 Kato M, Shukuya T, Takahashi F, Mori K, Suina K, Asao T, Kanemaru R, Honma Y, Muraki K, Sugano K, Shibayama R, Koyama R, Shimada N, Takahashi K.Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease.BMC Cancer Jul;14(1): 508, 2014 Nakashita T, Ando K, Kaneko N, Takahashi K, Motojima S.Potential risk of TNF inhibitors on the progression of interstitial lung disease in patients with rheumatoid arthritis.BMJ Open 4:e005615, 2014 Sato T, Suzuki Y, Mori T, Maeda M, Abe M, Hino O, Takahashi K.Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma.Cancer Med. Oct;3(5):1377-84, 2014 Ando K, Kaneko N, Doi T, Aoshima M, Takahashi K.Prevalence and risk factors of aortic aneurysm in patients with chronic obstructive pulmonary disease.J Thorac Dis. Oct;6(10):1388-95, 2014 Suzuki K, Seyama K, Hayashi T, Yamashiro Y, Shiraishi A, Kuwatsuru R.Reversed halo sign in tuberous sclerosis complex.Case Rep Radiol. 2013;2013:428501. Haga T, Kataoka H, Ebana H, Otsuji M, Seyama K, Tatsumi K, Kurihara M.Thoracic endometriosis-related pneumothorax distinguished from primary spontaneous pneumothorax in females.Lung. 2014 Aug;192(4):583-7. Kumasaka T, Hayashi T, Mitani K, Kataoka H, Kikkawa M, Tobino K, Kobayashi E, Gunji Y, Kunogi M, Kurihara M, Seyama K.Characterization of pulmonary cysts in Birt-Hogg-Dube syndrome: histopathological and morphometric analysis of 229 pulmonary cysts from 50 unrelated patients.Histopathology. 2014 Jul;65(1):100-10. Ainai A, Atsuta R, Shirabe K, Toda S, Wakabayashi-Takahara M, Morishima T, Ichiyama T.Cytokine profile of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during seasonal H1N1 infection.Hasegawa S, Wakiguchi H, Okada S, Gui Kang Y, Fujii N, Hasegawa M, Hasegawa H,Cytokine. 2014 Oct;69(2):206-10. Ito R, Gon Y, Nunomura S, Atsuta R, Harada N, Hattori T, Maruoka S, Okayama Y, Ra C, Hashimoto S.Development of assay for determining free IgE levels in serum from patients treated with omalizumab.Allergol Int. 2014 May;63 Suppl 1:37-47. Ko R, Kenmotsu H, Hisamatsu Y, Akamatsu H, Omori S, Nakashima K, Oyakawa T, Wakuda K, Shukuya T, Ono A, Imai H, Taira T, Naito T, Murakami H, Mori K, Endo M, Ohde Y, Takahashi K, Takahashi T.The effect of gefitinib in patients with postoperative recurrent non-small cell lung cancer harboring mutations of the epidermal growth factor receptor.Int J Clin Oncol. 2014 Oct 25. [Epub ahead of print] Shukuya T, Serizawa M, Watanabe M, Akamatsu H, Abe M, Imai H, Tokito T, Ono A, Taira T, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Ohde Y, Nakajima T, Yamamoto N, Koh Y.Identification of actionable mutations in malignant pleural mesothelioma.Lung Cancer. 2014 Oct;86(1):35-40. Akamatsu H, Koh Y, Kenmotsu H, Naito T, Serizawa M, Kimura M, Mori K, Imai H, Ono A, Shukuya T, Taira T, Murakami H, Ohde Y, Endo M, Nakajima T, Takahashi T, Yamamoto N.Multiplexed molecular profiling of lung cancer using pleural effusion.J Thorac Oncol. 2014 Jul;9(7):1048-52. Tokito T, Shukuya T, Akamatsu H, Ono A, Taira T, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Mori K, Yamamoto N.Toxicity and efficacy of chemotherapy for non-small cell lung cancer with cavitary lesions.Respir Investig. 2014 May;52(3):184-9. Shukuya T, Takahashi T, Imai H, Tokito T, Ono A, Akamatsu H, Taira T, Kenmotsu H, Naito T, Murakami H, Endo M, Yamamoto N.Comparison of cisplatin plus pemetrexed and cisplatin plus gemcitabine for the treatment of malignant pleural mesothelioma in Japanese patients.Respir Investig. 2014 Mar;52(2):101-6. Imai H, Shukuya T, Yoshino R, Muraki K, Mori K, Ono A, Akamatsu H, Taira T, Kenmotsu H, Naito T, Murakami H, Tomizawa Y, Takahashi T, Takahashi K, Saito R, Yamamoto N.Efficacy and safety of platinum combination chemotherapy re-challenge for relapsed patients with non-small-cell lung cancer after postoperative adjuvant chemotherapy of cisplatin plus vinorelbine.Chemotherapy. 2013;59(4):307-13. Akamatsu H, Mori K, Naito T, Imai H, Ono A, Shukuya T, Taira T, Kenmotsu H, Murakami H, Endo M, Harada H, Takahashi T, Yamamoto N.Progression-free survival at 2 years is a reliable surrogate marker for the 5-year survival rate in patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy.BMC Cancer. 2014 Jan 14;14:18. Imai H, Takahashi T, Mori K, Ono A, Akamatsu H, Shukuya T, Taira T, Kenmotsu H, Naito T, Murakami H, Endo M, Nakajima T, Yamamoto N.Individual-level data on the relationships of progression-free survival, post-progression survival, and tumor response with overall survival in patients with advanced non-squamous non-small cell lung cancer.Neoplasma. 2014;61(2):233-40. Wang XQ, Mao LJ, Fang QH, Kobayashi T, Kim HJ, Sugiura H, Kawasaki S, Togo S, Kamio K, Liu X, Rennard SI.Sphingosylphosphorylcholine induces α-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P2 receptor and Rho/Rho-kinase pathway.Prostaglandins Other Lipid Mediat. 2014 Jan;108:23-30. Li YJ, Kanaji N, Wang XQ, Sato T, Nakanishi M, Kim M, Michalski J, Nelson AJ, Farid M, Basma H, Patil A, Toews ML, Liu X, Rennard SI.Prostaglandin E2 switches from a stimulator to an inhibitor of cell migration after epithelial-to-mesenchymal transition.Prostaglandins Other Lipid Mediat. 2014 Oct 31;116-117C:1-9. Kanaji N, Basma H, Nelson A, Farid M, Sato T, Nakanishi M, Wang X, Michalski J, Li Y, Gunji Y, Feghali-Bostwick C, Liu X, Rennard SI.Fibroblasts that resist cigarette smoke-induced senescence acquire profibrotic phenotypes.Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1;307(5):L364-73. Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H.OX40 ligand regulates splenic CD8- dendritic cell-induced Th2 responses in vivo.Biochem Biophys Res Commun. 2014 Feb 7;444(2):235-40. Yagishita S, Horinouchi H, Katsui Taniyama T, Nakamichi S, Kitazono S, Mizugaki H, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Sumi M, Shiraishi K, Kohno T, Furuta K, Tsuta K, Tamura T.Epidermal Growth Factor Receptor Mutation Is Associated With Longer Local Control After Definitive Chemoradiotherapy in Patients With Stage III Nonsquamous Non-Small-Cell Lung Cancer.Int J Radiat Oncol Biol Phys. 2014 Oct 13. pii: S0360-3016(14)04051-6. Mizugaki H, Fujiwara Y, Yamamoto N, Yagishita S, Kitazono S, Tanaka A, Horinouchi H, Kanda S, Nokihara H, Tsuta K, Asamura H, Tamura T.Adjuvant chemotherapy in patients with completely resected small cell lung cancer: a retrospective analysis of 26 consecutive cases.Jpn J Clin Oncol. 2014 Sep;44(9):835-40. Yagishita S, Horinouchi H, Yorozu T, Kitazono S, Mizugaki H, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Mori T, Tsuta K, Sumi M, Tamura T.Secondary osteosarcoma developing 10 years after chemoradiotherapy for non-small-cell lung cancer.Jpn J Clin Oncol. 2014 Feb;44(2):191-4. 英文業績（2013） Ando K, Kurihara M, Kataoka H, Ueyama M, Togo S, Sato T, Doi T, Iwakami S, Takahashi K, Seyama K, Mikami MThe efficacy and safety of low-dose sirolimus for treatment of lymphangioleiomyomatosis.Respiratory Investigation,2013;51: 175-83 Ando K, Motojima S, Doi T, Nagaoka T, Kaneko N, Aoshima M, Takahashi K.Effect of glucocorticoid monotherapy on pulmonary function and survival in Japanese patients with scleroderma-related interstitial lung disease.Respiratory Investigation,2013;51: 69-75 Ando K, Nakashita T, Kaneko N, Takahashi K, Motojima S. Long-term efficacy and safety of maintenance therapy with azathioprine or cyclosporine for interstitial lung disease with diffuse cutaneous scleroderma.Clin Exp Rheumatol,2013;31:191-192 Ando K, Sekiya M, Tobino K, Takahashi KRelationship between quantitative CT metrics and pulmonary function in combined pulmonary fibrosis and emphysemaLung,2013;191:585-591 Ando K, Takahashi F, Motojima S, Nakashima K, Kaneko N, Hoshi K, Takahashi K.Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexiaJ of Clin Oncology,2013;31:e69-e72 Ando K, Takahashi F, Takahashi K.Reply to Berti et al.J Clin Oncol 2013; 31: 2971 Babaei Jandaghi A, Daliri S, Kikkawa M, Khaledi M, Soleimanifar N, Alizadeh A, Habibzadeh M, Haghi-Ashtiani MT, Seyama K, Rezaei NThe discovery of a Persian family with a form of Birt-Hogg-Dube syndrome lacking the typical cutaneous stigmata of the syndromeClin Imaging,2013;37: 111-115 Hoshika Y, Hamamoto T, Sato K, Eto H, Kuriyama S, Yoshimi K, Iwakami S, Takahashi K, Seyama KPrevalence and clinical features of lymphedema in patients with lymphangioleiomyomatosis.Respir Med,2013;107:1253-1259 Hosokawa M, Kenmotsu H, Koh Y, Yoshino T, Yoshikawa T, Naito T, Takahashi T, Murakami H, Nakamura Y, Tsuya A, Shukuya T, Ono A, Akamatsu H, Watanabe R, Ono S, Mori K, Kanbara H, Yamaguchi K, Tanaka T, Matsunaga T, Yamamoto NSize-based isolation of circulating tumor cells in lung cancer patients using a microcavity array system.PLoS One,2013;8: e67466 Imai H, Shukuya T*, Takahashi T, Fujiwara S, Mori K, Ono A, Akamatsu H, Taira T, Kenmotsu H, Naito T, Kaira K, Murakami H, Harada H, Endo M, Nakajima T, Yamamoto N.Comparison of the time-to-response between radiotherapy and epidermal growth factor receptor - tyrosine kinase inhibitors for advanced non-small cell lung cancer with EGFR mutationAnticancer Res,2013;33:3279-3284 Ishiwata T, Seyama K, Hirao T, Shimada K, Morio Y, Miura K, Kume A, Takagi H, Takahashi K.Improvement in skin color achieved by smoking cessation.Int J Cosmet Sci,2013;35:191-195 Iwakami S, Fujii M, Ishiwata T, Iwakami N, Hara M, Ihara H, Wada R, Tsutsumi T, Seyama K, Takahashi KSmall-cell lung cancer exhibiting spontaneous regressionIntern Med,2013;52: 2249-2252 Kaira K, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Ono A, Naito T, Tsuya A, Nakamura Y, Endo M, Kondo H, Nakajima T, Yamamoto NThe role of βIII-tubulin in non-small cell lung cancer patients treated by taxane-based chemotherapyInt J Clin Oncol,2013;18: 371-379 Kanaji N, Nelson A, Wang X, Sato T, Nakanishi M, Gunji Y, Basma H, Michalski J, Farid M, Rennard SI,Liu X. Differential roles of JNK, ERK1/2, and p38 mitogen-activated protein kinases on endothelial cell tissue repairJ Vasc Res,2013;50:145-156 Kato M, Tobino K, Fujimoto Y, Kobayashi I, Sugano K, Tokuda H, Ienaga H, Takahashi KPneumocystis pneumonia induced by treatment with low-dose tacrolimus and methylprednisolone in a patient with rheumatoid arthritis: a case reportBMC Res Notes,2013;6: 498 Koike K, Ishigami A, Sato Y, Hirai T, Yuan Y, Kobayashi E, Tobino K, Sato T, Sekiya M, Takahashi K, Fukuchi Y, Maruyama N, Seyama KVitamin C Prevents Cigarette Smoke-Induced Pulmonary Emphysema in Mice and Provides Pulmonary RestorationAm J Respir Cell Mol Biol,2013,50(2)：347-57 Miyanaga A, Shimizu K, Noro R, Seike M, Kitamura K, Kosaihira S, Minegishi Y, Shukuya T, Yoshimura A, Kawamoto M, Tsuchiya S, Hagiwara K, Soda M, Takeuchi K, Yamamoto N, Mano H, Ishikawa Y, Gemma AActivity of EGFR-tyrosine kinase and ALK inhibitors for EML4-ALK-rearranged non-small-cell lung cancer harbored coexisting EGFR mutationBMC Cancer,2013;13: 262 Mochizuki H, Nanjo Y, Takahashi HBetter adherence to a transdermal tulobuterol patch than inhaled salmeterol in elderly COPD patients.Geriat Geront Int,2013;10: 398-404 Mori T, Tajima K, Hirama M, Sato T, Kido K, Iwakami S, Sasaki S, Iwase A, Shiomi K, Maeda M, Hino O, Takahashi KThe N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma.J Thoracic Diseases,2013;5:145-148 Murakami A, Takahashi F, Nurwidya F, Kobayashi I, Minakata K, Hashimoto M, Nara T, Kato M, Tajima K, Shimada N, Iwakami S, Moriyama M, Moriyama H, Koizumi F, Takahashi K.Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.PLoS One,2013;28;9(1):e86459 Nagahama KY, Togo S, Holz O, Magnussen H, Liu X, Seyama K, Takahashi K, Rennard SI. Oncostatin Mmodulates fibroblast function via signal ttransducers and activators of transcription proteins-3Am J Respir Cell Mol Biol,2013;49:582-591 Nagashima O, Matsuno K, Tominaga S, Takahashi KEsophageal diverticulum with idiopathic pulmonary upper lobe fibrosisInternal Medicine,2013;52:59 Nagashima O, Ohashi R, Yoshioka Y, Inagaki A, Tajima M, Koinuma Y, Iwakami S, Iwase A, Sasaki S, Tominaga S, Takahashi KHigh prevalence of gene abnormalities in young patients with lung cancerJ Thorac Dis.,2013;5:27-30 Nanjo Y, Ishii Y, Kimura S, Fukami T, Mizoguchi M, Suzuki T, Tomono K, Akasaka Y, Ishii T, Takahashi K, Tateda K, Yamaguchi K.Effects of slow-releasing colistin microspheres on emdotoxin-induced sepsis.J Infect Chemother,2013;19:683-90 Nurwidya F, Takahashi F, Murakami A, Kobayashi I, Kato M, Shukuya T, Tajima K, Shimada N, Takahashi K.Acquired resistance of non-small cell lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.Respir Investig,2013;52(2):82-91 Ono A, Takahashi T, Mori K, Akamatsu H, Shukuya T, Taira T, Kenmotsu H, Naito T, Murakami H, Nakajima T, Endo M, Yamamoto N.Prognostic impact of serum CYFRA 21-1 in patients with advanced lung adenocarcinoma: a retrospective studyBMC Cancer,2013;13:354 Ono A, Takahashi T, Oishi T, Sugino T, Akamatsu H, Shukuya T, Taira T, Kenmotsu H, Naito T, Murakami H, Nakajima T, Endo M, Yamamoto N.Acute lung injury with alveolar hemorrhage as adverse drug reaction related to crizotinibJ Clin Oncol,2013;31:e417-9 Sasaki M, Mochizuki H, Takahashi HBronchoesophageal fistula developing shortly after initiation of antituberculous chemotherapy.Internal Medicine,2013;52:376-380 Sekiya K, Taniguchi M, Fukutomi Y, Watai K, Minami T, Hayashi H, Ito J, Tanimoto H, Oshikata C, Tsurikisawa N, Tsuburai T, Hasegawa M, Akiyama KAge-Specific characteristics of inpatients with severe asthma exacerbation.Allergol Int,2013;62:331-336 Sekiya M, Yoshimi K, Muraki K, Suzuki K, Dambara T, Toshimasa U, Takahashi K.Solitary Fibrous Tumor of the Pleura: Ultrasonographic Imaging Findings of Three Cases.Respiratory Investigation,2013;51:200-204 Shiota S, Takekawa H, Matsumoto SE, Takeda K, Nurwidya F, Yoshioka Y, Takahashi F, Hattori N, Tabira T, Mochizuki H, Takahashi K.Chronic Intermittent Hypoxia/Reoxygenation Facilitate Amyloid-β Generation in MiceJ Alzheimers Dis,2013;37:325-333 Shukuya T, Takahashi T, Harada H, Ono A, Akamatsu H, Taira T, Kenmotsu H, Naito T, Murakami H, Endo M, Takahashi K, Yamamoto NChemoradiotherapy for limited-desease small-cell lung cancer in elderly patients aged 75 years or older.Jpn J Clin Oncol,2013;43:176-183 Shukuya T, Takahashi T, Imai H, Tokito T, Ono A, Akamatsu H, Taira T, Kenmotsu H, Naito T, Murakami H, Endo M, Yamamoto N.Comparison of cisplatin plus pemetrexed and cisplatin plus gemcitabine for malignant pleural mesothelioma in Japanese patients.Respir Investig,2013;52(2):101-6 Togo S, Polanska U, Horimoto Y, Orimo ACancer-associated fibroblasts are promising thrapeutic target.Cancers,2013;5:149-169 Tokito T, Shukuya T, Akamatsu H, Taira T, Ono A, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Yamamoto NEfficacy of bevacizumab-containing chemotherapy for non-squamous non-small cell lung cancer with bone metastases.Cancer Chemother Pharmacol,2013;71:1493-1498 Wang X, Nelson A, Weiler ZM, Patil A, Sato T, Kanaji N, Nakanishi M, Michalski J, Farid M, Basma HLeVan TD, Miller-Lasson A, Wieslander E, Muller KC, Holz O, Magnussen H, Rabe KF, Liu X, Rennard SI. Anti-inflammatory effects of budesonide in human lung fibroblasts are independent of histone deacetylase 2J Inflamm Res,2013;6: 109-119 Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano OxCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinomaCancer Res,2013;73:1855-66 英文業績（2012） Ando K, Doi T, Moody S.Y, Ohkuni Y, Sato A, Kaneko N. The effect of comorbidity on the prognosis of acute lung injury and acute respiratory distress syndrome. Internal Medicine 51:1835-1840, 2012 Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proc Natl Acad Sci USA. 109(8): 2760-6, 2012 Fujii M, Iwakami SI, Takagi H, Itoigawa Y, Ichikawa M, Iwakami N, Ishiwata T, Seyama K, Takahashi K. Factors influencing weaning from mechanical ventilation in elderly patients with severe pneumonia. Geriatr Gerontol Int. 12(2): 277-83, 2012 Kanaji N, Nelson A, Allen-Gipson DS, Sato T, Nakanishi M, Wang X, Li Y, Basma H, Michalski J, Farid M, Rennard SI, Liu X. The p38 mitogen-activated protein kinases modulate endothelial cell survival and tissue repair. Inflamm Res. 61(3):233-44, 2012 Nagashima O, Iwase A, Yae T, Kadoya K, Ishimori A, Kuriyama S, Koyama R, Homma N, Ienaga H, Takahashi K. A case of pseudomembranous aspergillus tracheobronchitis in an asthma patient receiving inhaled corticosteroid therapy. The Journal of the Japan Society for Respiratory Endoscopy(気管支学) 34(1):71-73, 2012 Nakanishi M, Sato T, Li Y, Nelson A, Farid M, Michalski J, Kanaji N, Wang X, Basma H, Patil A, Goraya J, Liu X, Togo S, Toews ML, Holz O, Muller K, Magnussen H, Rennard SI. Prostaglandin E2 stimulates the production of vascular endothelial growth factor through the E-pristanoid-2 receptor in cultured human lung fibroblasts. Am J Respir Cell Mol Biol. 46(2): 217-23, 2012 Okuzumi A, Kimura T, Katsura Y, Miyaji A, Hirama M, Kido K, Ogura K, Hishii M, Takahashi K. Pulmonary Metastases from carotid body paraganglioma: a case report. Juntendo Medical Journal(順天堂医学) 58(1):65-68, 2012 Shukuya T, Takahashi T, Harada H, Akamatsu H, Sakaguchi C, Imai H, Ono A, Nakamura Y, Tsuya A, Kenmotsu H, Naito T, Murakami H, Endo M, Takahashi K, Yamamoto N. Comparison of vinorelbine plus cisplatin and s-1 plus cisplatin in concurrent chemoradiotherapeutic regimens for unresectable stage III non-small cell lung cancer. Anticancer Res. 32(2): 675-80, 2012 Tobino K, Hirai T, Johkoh T, Kurihara M, Fujimoto K, Tomiyama N, Mishima M, Takahashi K, Seyama K. Differentiation between Birt-Hogg Dube　syndrome and lymphangioleiomyomatosis: Quantitative analysis of pulmonary cysts on computed tomography of the chest in 66 females. Eur J Radiol. 81(6): 1340-1346, 2012 Muraki K, Koyama R, Honma Y, Yagishita S, Shukuya T, Ohashi R, Takahashi F, Kido K, Iwakami S, Sasaki S, Iwasse A, Takahashi K. Hydration with magnesium and mannitol eithout furosemide prevents the nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced non-small cell lung cancer. J Thorac Dis. 4(6):562-568,2012 Nagashima O, Ohashi R, Yoshioka Y, Inagaki A, Tajima M, Koinuma Y, Iwakami S, Iwase A, Sasaki S, Tominaga S, Takahashi K. High prevalence of gene abnormalities in young patients with lung cancer. J Thorac Dis. 5(1):27-30,2013 Koyama R, Miura K, Yae S, Murakami A, Takahashi K. Effect of Continuation of Chemotherapy on Quality of Life in Elderly Patients with Lung Cancer ?Comparison with That in Younger Patients-. Juntendo Medical Journal. 58(6):506-511,2012 Minakata K, Takahashi F, Nara T, Hashimoto M, Tajima K, Murakami A, Nurwidya F, Yae S, Koizumi F, Moriyama H, Seyama K, Nishio K, Takahashi K. Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors. 103(11):1946-1954,2012 Kaira K, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Hayashi I, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N. 18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study. European Journal of Radiology. 81:2423-2429,2012 Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshioka M, Yoshida J. G, Wada T, Masuko T, Mogushi K, Tanaka H, Osawa T, Kanki Y, Minami T, Aburatani H, Ohmura M, Kubo A, Suematsu M, Takahashi K, Saya H, Nagano O. Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nature Communications: DOI:10.1038/ncomms1892, 2012[in press] Yae S, Takahashi F, Yae T, Yamaguchi T, Tsukada R, Koike K, Minakata M, Murakami A, Nurwidya F, Kato M, Tamada M, Yoshikawa M, Kobayashi H, Seyama K, Takahashi K. Hochuekkito(TJ-41), a Kampo Formula, Ameliorates Cachexia Induced by Colon 26 Adenocarcinoma in Mice. 2012[in press] Yoshimi K, Ueki J, Seyama K, Takizawa M, Yamaguchi S, Kitahara E, Fukazawa S, Takahama Y, Ichikawa M, Takahashi, Fukuchi Y. Pulmonary rehabilitation program including respiratory conditioning for chronic obstructive pulmonary disease (COPD): Improved hyperinflation and expiratory flow during tidal breathing. J Thorac Dis 4(3):259-264, 2012 Makino F, Ito J, Abe Y, Harada N, Kamachi F, Y Hideo, Takahashi K, Okumura K, Akiba H. Blockade of CD70-27 Interaction Inhibits Induction of Allergic Lung Inflammation in Mice. Am J Respir Cell Mol Biol 47(3): 298-305, 2012 Ando K, Tobino K, Kurihara M, Kataoka H, Doi T, Hoshika Y, Takahashi K, Seyama K. Quantitative CT analysis of small pulmonary vessels in Lymphangioleiomyomatosis. European Journal of Radiology. 81: 3925-3930, 2012 Muraki K, Koyama R, Homma Y, Yagishita S, Shukuya T, Takahashi F, Ohashi R, Takahashi K. Hydration with magnesium and mannitol without furosemide prevents the nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced non-small cell lung cancer. J Thorac Dis. 4(6): 562-8, 2012 Ohwada A, Takahashi K. Concave pattern of a maximal expiratory flow-volume cueve: a sign of airflow limitation in adult bronchial asthma. Pulmonary Mdeicine. 2012 in press Ando K ,Takahashi F, Motojima S, Nakashima K, Kaneko N, Hoshi K, Takahashi K. Possible Role for Tocilizumab, an Anti-Interleukin-6 Receptor Antibody, in Treating Cancer Cachexia. Journal of Clinical Oncology 31(6): 69-72, 2013 Ando K, Kurihara M, Kataoka H, Ueyama M, Togo S, Sato T, Doi T, Iwakami S, Takahashi K, Seyama K, Mikami M. The efficacy and safety of low-dose sirolimus in lymphangioleiomyomatosis. Respiratory Investigation, Available online 2013 Babaei Jandaghi A, Daliri S, Kikkawa M, Khaledi M, Soleimanifar N, Alizadeh A, Habibzadeh M, Haghi-Ashtiani MT, Seyama K, Rezaei N. The discovery of a Persian family with a form of Birt-Hogg-Dube syndrome lacking the typical cutaneous stigmata of the syndrome. Clin Imaging. 37: 111-115, 2013 Ishiwata T, Seyama K, Hirao T, Shimada K, Morio Y, Miura K, Kume A, Takagi H, Takahashi K. Improvement in skin color achieved by smoking cessation. Int J Cosmet Sci. 35(2): 191-5, 2013 Sasaki M,Mochizuki H,Takahashi H. Bronchoesoph ageal fistula developing shortly after initiation of antituberculous chemotherapy. Internal Medicine 2013 52: 376-380 Mochizuki H, Nanjo Y, Takahashi H. Better adherence to a transdermal tulobuterol patch than inhaled salmeterol in elderly COPD patients. Geriat Geront Int 10: 398-404, 2013 Mori T, Tajima K, Hirama M, Sato T, Kido K, Iwakami S, Sasaki S, Iwase A, Shiomi K, Maeda M, Hino O, Takahashi K. The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma. J Thorac Dis 5(2): 145-148, 2013 Nagashima O, Matsuno K, Tominaga S, Takahashi K. Esophageal diverticulum with idiopathic pulmonary upper lobe fibrosis. Intern Med 52: 159, 2013. Nagashima O, Ohashi R, Yoshioka Y, Inagaki A, Tajima M, Koinuma Y, Iwakami S, Iwase A, Sasaki S, Tominaga S, Takahashi K. High prevalence of gene abnormalities in young patients with lung cancer. J Thorac Dis. 5(1): 27-30, 2013 Nanjo Y, Ishii Y, Kimura S, Fukami T, Mizoguchi M, Suzuki T, Tomono K, Akasaka Y, Ishii T, Takahashi K, Tateda K, Yamaguchi K. Effects of slow-releasing colistin microspheres on emdotoxin-induced sepsis. J Infect Chemother. DOI: 10.1007/s10156-012-0544-y, 2013 Jan 25[Epub ahead of print] Sasaki M, Mochizuki H, Takahashi H. Bronchoesophageal fistula developing shortly after initiation of antituberculous chemotherapy. Internal Medicine 52: 376-380, 2013 Sekiya M, Yoshimi K, Muraki K, Suzuki K, Dambara T, Toshimasa U, Takahashi K. Solitary Fibrous Tumor of the Pleura: Ultrasonographic Imaging Findings of Three Cases. Respiratory Investigation, 2013 (in press) Shukuya T, Takahashi T, Harada H, Ono A, Akamatsu H, Taira T, Kenmotsu H, Naito T, Murakami H, Endo M, Takahashi K, Yamamoto N. Chemoradiotherapy for limited-desease small-cell lung cancer in elderly patients aged 75 years or older. Jpn J Clin Oncol. 43(2): 176-183, 2013 Togo S, Polanska U, Horimoto Y, Orimo A. Cancer-associated fibroblasts are promising thrapeutic target.　Cancers Jun 5:149-169, 2013 (Revision中) Nakagawa N, Saito Y, Sasaki M, Tsuda Y, Mochizuki H, Takahashi H. Comparison of clinical profile in elderly patients with nursing and healthcare-associated pneumonia and those with community-acquired pneumonia (Revision中) Shiota S,Takekawa H,Matsumoto S,Takeda K,Nurwidya F,Yoshioka Y,Takahashi F,Hattori N,Tabira T,Mochizuki H,Takahashi K. Chronic Intermittent Hypoxia/Reoxygenation Facilitate Amyloid-β Generation in Mice.Journal of Alzheimer’s Disease 37:325-333,2013 Shiota S,Inoue Y,Takekawa H,Kotajima M,Nakajyo M,Usui C,Yoshioka Y,Koga T,Takahashi K. Effect of continuous positive airway pressure on regional cerebral blood flow during wakefulness on obstructive sleep apnea.Sleep Breath Sep,2013 Ando K,Nakashita T,Kaneko K,Takahashi K,Motojima S. Long-term efficacy and safety of maintenance therapy with azathioprine or cyclosporine for interstitial lung disease with diffuse cutaneous scleroderma.Letter to the editor S191-192,2013 Ando K,Sekiya M,Tobino K,Takahashi K. Relationship Between Quantitative CT Metrics and Pulmonary Function in Combined Pulmonary Function in Combined Pulmonary Fibrosis and Emphysema.Long Oct 02,2013 英文業績（2011） Benhammou JN, Vocke CD, Santani A, Schmidt LS, Baba M, Seyama K, Wu X, Korolevich S, Nathanson KL, Stolle CA, Linehan WM. Identification of intragenic deletions and duplication in the FLCN gene in Birt-Hogg-Dube syndrome. Genes Chromosomes Cancer 50(6):466-77, 2011 Hagiwara K, Morino H, Shiihara J, Tanaka T, Miyazawa H, Suzuki T, Kohda M, Okazaki Y, Seyama K, Kawakami H. Homozygosity mapping on homozygosity haplotype analysis to detect recessive disease-causing genes from a small number of unrelated, outbred patients. PLoS One. 6(9):e25059, 2011 Hayashi T, Kumasaka T, Mitani K, Terao Y, Watanabe M, Oide T, Nakatani Y, Hebisawa A, Konno R, Takahashi K, Yao T, Seyama K. Prevalence of uterine and adnexal involvement in pulmonary lymphangioleiomyomatosis: a clinicopathologic study of 10 patients. Am J Surg Pathol. 35(12): 1776-85, 2011 Hayashida M, Seyama K, Inoue Y, Hirai T, Mishima M; Respiratory failure research group; Japanese Ministry of Health, Labor, and Welfare. Criteria for designation of lymphangioleiomyomatosis in the specified disease treatment research program. Nihon Kokyuki Gakkai Zasshi. 49(2): 67-74, 2011 Honda A, Yanagawa M, Inoue A, Kikuyama A, Yoshida S, Sumikawa H, Tobino K, Koyama M, Tomiyama N. Image quality of multiplanar reconstruction of pulmonary CT scans using adaptive statistical iterative reconstruction. Br J Radiol. 84(1000): 335-41, 2011 Inomata M, Shukuya T, Takahashi T, Ono A, Nakamura Y, Tsuya A, Kenomotsu H, Naito T, Murakami H, Harada H, Endo M, Yamamoto N. Continuous administration of EGFR-TKIs following radiotherapy after disease progression in bone lesions for non-small-cell lung cancer. Anticancer Res. 31: 4519-23, 2011 Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H. CD44 Variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc- and thereby promotes tumor growth. Cancer Cell 19(8): 387-400, 2011 Ishiwata T, Hirose T, Hirama M, Miura K, Iwakami S, Tominaga S, Adachi M, Takahashi K. A feasibility study of zoledronic acid combined with carboplatin/nedaplatin plus paclitaxel in patients with non-small cell lung cancer with bone metastases. Tumori 97:568-572, 2011 Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, Okumura K, Dorscheid R. D, Atsuta R, Akiba H, Takahashi K. Wound-induced TGF-β1 and TGF-β2 enhance airway epithelial repair via HB-EGF and TGF-α. Biochemical and Biophysical Research Communications 412:109-114, 2011 Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N. L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma. Anticancer Res. 31: 4075-82, 2011 Kaira K, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Oriuchi N, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N.　Relationship between LAT1 expression and response to platinum-based chemotherapy in non-small cell lung cancer patients with postoperative recurrence. Anticancer Res. 31: 3775-82, 2011 Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N. LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer. Am J Transl Res. 3: 468-78, 2011 Kanaji N, Sato T, Nelson A, Wang X, Li Y, Kim M, Nakanishi M, Basma H, Michalski J, Farid M, Chandler M, Pease W, Patil A, Rennard SI, Liu X. Inflammatory cytokines regulate endothelial cell survival and tissue repair functions via NF-kB signaling. J Inflamm Res 4: 127-38, 2011 Kato M, Shiota S, Shiga K, Takagi H, Mori H, Sekiya M, Suzuki K, Uekusa T, Takahashi K. Benign giant mediastinal schwannoma presenting as cardiac tamponade in a woman: a case report. J Med Case Rep. 14;5:61, 2011 Li YJ, Wang XQ, Sato T, Kanaji N, Nakanishi M, Kim M, Michalski J, Nelson AJ, Sun JH, Farid M, Basma H, Patil A, Toews Ml, Liu X, Rennard SI. Prostaglandin E2 inhibits human lung fibroblast chemotaxis through disparate actions on different E-prostanoid receptors. Am J Respir Cell Mol Biol 44(1):99-107, 2011 Motohara T, Masuko S, Ishimoto T, Yae T, Onishi N, Muraguchi T, Hirao A, Matsuzaki Y, Tashiro H, Katabuchi H, Saya H, Nagano O. Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells. Carcinogenesis 32(11): 1597-606, 2011 Nagahama K, Hayashi T, Nagaoka T, Kanemaru R, Togo S, Kumasaka T, Uekusa T, Seyama K, Takahashi K. Pulmonary erdheim-chester disease: A response to predonisolone. Respiratory Medicine CME 4: 81-84, 2011 Ohwada A, Inami K, Matsumoto- Yamazaki M, Atsuta R, Takahashi K. Bronchial reversibility with a short-acting β2-agonist predicts the FEV1 response to administration of a along-acting β2-agonist with inhaled corticosteroids in patients with bronchial asthma. Experimental and Therapeutic Medicine 2: 619-623, 2011 Ohashi R, Kato M, Katsura Y, Takekawa H, Hoshika Y, Sugawara T, Yoshimi K, Togo S, Nagaoka T, Seyama K, Takahashi K, Tsuchiya K, Misawa S, Kikuchi K. Breakthrough lung scedosporium prolificans infection with multiple cavity lesions in a patient receiving voriconazole for probable invasive aspergillosis associated with monoclonal gammopathy of undetermined significance(MGUS). Med. Mycol. J. 52:33-38, 2011 Sato T, Liu X, Basma H, Togo S, Sugiura H, Nelson A, Nakanishi M, Kanaji N, Wang X, Kim M, Li Y, Michalski J, Farid M, Sharp JG, Rennard SI. Interleukin-4 induces differentiation of human embryonic stem cells into“fibrogenic”fibroblast-like cells. J Allergy Clin Immun 127: 1595-1603, 2011 Shiomi K, Shiomi S, Ishinaga Y, Sakuraba M, Hagiwara Y, Miyashita K, Maeda M, Suzuki K, Takahashi K, Hino O. Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and osteopontin. Anticancer Research 31:1427-1430, 2011 Shukuya T, Takahashi T, Kaira R, Ono A, Nakamura Y, Tsuya A, Kenmotsu H, Naito T, Kaira K, Murakami H, Endo M, Takahashi K, Yamamoto N. Efficacy of gefitinib for non-adenocarcinoma non-small-cell lung cancer patients harboring epidermal growth factor receptor mutations: a pooled analysis of published reports. Cancer Sci. 102(5): 1032-1037, 2011 Shukuya T, Takahashi T, Naito T, Kaira R, Ono A, Nakamura Y, Tsuya A, Kenmotsu H, Murakami H, Harada H, Mitsuya K, Endo M, Nakasu Y, Takahashi K, Yamamoto N. Continuous EGFR-TKI administration following radiotherapy for non-small cell lung cancer patients with isolated CNS failure. Lung Cancer 74(3): 457-61, 2011 Tajima K, Miura K, Ishiwata T, Takahashi F, Yoshioka M, Minakata K, Murakami A, Sasaki S, Iwakami S, Annoura T, Hashimoto M, Nara T, Takahashi K. Sex hormones alter Th1 responses and enhance granuloma formation in the lung. Respiration 81(6): 491-498, 2011 Takahashi F, Chiba N, Tajima K, Hayashida T, Shimada T, Takahashi M, Moriyama H, Brachtel E, Edelman EJ, Ramaswamy S, Maheswaran S. Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib. Oncogene 30(27): 3084-95, 2011 Tobino K, Gunji Y, Kurihara M, Kunogi M, Koike K, Tomiyama N, Johkoh T, Kodama Y, Iwakami S, Kikkawa M, Takahashi K. Seyama K. Characteristics of pulmonary cysts in Birt-Hogg-Dube syndrome: thin-section CT findings of the chest in 12 patients. Eur J Radiol. 77(3):403-409, 2011 Togo S, Sato T, Sugiura H, Wang X, Basma H, Nelson A, Liu X, Bargar TW, Sharp JG, Rennard SI. Differentiation of embryonic stem cells into fibroblast-like cells in three-dimensional type I collagen gel cultures. In Vitro Cell Dev Biol Animal 47(2): 114-24, 2011 英文業績（2010） Tajima K, Ohashi R, Sekido Y, Hida T, Nara T, Hashimoto M, Iwakami S, Minakata K, Yae T, Takahashi F, Saya H, Takahashi K.Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells.Oncogene. 2010; 29(13):1941-1951. Koike K, Kondo Y, Sekiya M, Sato Y, Tobino K, Iwakami S, Goto S, Takahashi K, Maruyama N, Seyama K, Ishigami A.Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice.Am J Physiol Lung Cell Mol Physiol. 2010; 298: L784-L792. Kunogi M, Kurihara M, Shigihara T, Ikegami, Kobayashi T, Shindo N, Kumasaka T, Gunji Y, Kikkawa M, Iwakami S, Hino O, Takahashi K, Seyama K.Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.J. Med. Genet. 2010; 47:281-287. Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J.A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations.Cell. 2010; 141(1):69-80. Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco MM, Wijendran V, Shioda T, Sgroi D, Donahoe PK, Maheswaran S.HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.Proc Natl Acad Sci USA. 2010; 107(3):1100-5. Sato T, Liu X, Nelson A, Nakanishi M, Kanaji N, Wang X, Kim M, Li Y, Sun J, Michalski J, Patil A, Basma H, Holz O, Magnussen.Reduced miR-146a increases prostaglandin E2 in chronic obstructive pulmonary disease fibroblasts.Am J Respir Crit Care Med. 2010; 182:1020-1029. Seyama K, Kumasaka T, Kurihara M, Mitani K, Sato T.Lymphangioleiomyomatosis: a disease involving the lymphatic system.Lymphat Res Biol. 2010; 8: 21-31. Seyama K, Mitani K, Kumasaka T, Gupta SK, Oommen S, Liu G, Ryu JH, Vlahakis NE. Lymphangioleiomyoma cells and lymphatic endothelial cells: expression of VEGFR-3 in lymphangioleiomyoma cell clusters.Am J Pathol. 2010; 176: 2051-2052 Toba M, Nagaoka T, Morio Y, Sato K, Uchida K, Homma N, Takahashi K.Involvement of Rho kinase in the pathogenesis of acute pulmonary embolism-induced polystyrene microspheres in rats.Am J Physiol Lung Cell Mol Physiol. 2010; 298(3): L297-L303. Hayashi T, Kumasaka T, Mitani K, Yao T, Suda K, Seyama K.Loss of heterozygosity on tuberous sclerosis complex genes in multifocal micronodular pneumocyte hyperplasia.Mod Pathol. 2010; 23: 1251-1260. Huqun, Fukuyama S, Morino H, Miyazawa H, Tanaka T, Suzuki T, Kohda M, Kawakami H, Okazaki Y, Seyama K, Hagiwara K.A quantitatively-modeled homozygosity mapping algorithm, qHomozygosityMapping, utilizing whole genome single nucleotide polymorphism genotyping data.BMC Bioinformatics 11 Suppl. 2010; 7:S5. Ichikawa M, Iwakami S, Fujii M, Takahashi K.A Rare image of a pulmonary nodule revealed on FDG-PET scans.Inter Med. 2010; 49: 2275-2276. Ishiwata T, Sekiya M, Suzuki T, Matsuoka T, Kumasaka T, Takahashi K.Thymic adenocarcinoma with sarcomatoid features characterized by intracaval tumor growth: report of a case.Surg Today. 2010; 40: 1068-1072. Ichinose M, Seyama K, Nishimura M, Fukuchi Y, Nagai A, Mishima M, Kubo K; Beta-2 Agonist Research and Evaluation Committee in COPD (BAREC) Study Group.Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD.Respir Med. 2010; 104: 267-274. Igawa S, Murakami H, Takahashi T, Nakamura Y, Tsuya A, Naito T, Kaira K, Ono A, Shukuya T, Tamiya A, Endo M, Yamamoto N.Efficacy of chemotherapy with carboplatin and paclitaxel for unresectable thymic carcinoma.Lung Cancer. 2010; 67:194-197. Jiang DM, Kato C, Zhou XW, Wu ZH, Sato T, Li YZ.Phylogeographic separation of marine ando soil myxobacteria ato high levels of classification.ISME J. 2010; 4(12): 1520-1530. Kaira K, Naito T, Takahashi T, Ayabe E, Shimoyama R, Kaira R, Ono A, Igawa S, Shukuya T, Murakami H, Tsuya A, Nakamura Y, Endo M, Yamamoto N.Pooled analysis of the reports of erlotinib after failure of gefitinib for non-small cell lung cancer.Lung Cancer. 2010; 68: 99-104. Kamio K, Liu XD, Sugiura H, Togo S, Kawasaki S, Wang X, Ahn Y, Hogaboam C, Rennard SI.Statins inhibit matrix metalloproteinase release from human lung fibroblasts.Eur Respir J. 2010; 35(3):637-46. Malinowska-Kolodziej I, Finlay G, Campbell G, Garcia-Moliner ML, Weinstein B, Doughty CA, Qin W, Butterfield C, Short S, Seyama K, Kwiatkowski DJ.Lymphangioleiomyomatosis: cause of a malignant chylous pleural effusion.J Clin Oncol. 2010; 28: 4-6. Nurok M, Eslick I, Carvalho CR, Costabel U, D'Armiento J, Glanville AR, Harari S, Henske EP, Inoue Y, Johnson SR, Lacronique J, Lazor R, Moss J, Ruoss SJ, Ryu JH, Seyama K, Watz H, Xu KF, Hohmann EL, Moss F.The International LAM Registry: a component of an innovative web-based clinician, researcher, and patient-driven rare disease research platform.Lymphat Res Biol. 2010; 8: 81-87. Ono A, Naito T, Murakami H, Takahashi T, Nakamura Y, Tsuya A, Kaira K, Igawa S, Shukuya T, Tamiya A, Kaira R, Endo M, Yamamoto N.Evaluation of S-1 as third- or further-line chemotherapy in advanced non-small-cell lung cancer.Int J Clin Oncol. 2010; 15: 161-165. Shukuya T, Takahashi T, Tamiya A, Ono A, Igawa S, Nakamura Y, Tsuya A, Murakami H, Endo M, Ohde Y, Nakagawa K, Okumura T, Kondo H, Yamamoto N.Actual status of adjuvant chemotherapy for non-small-cell lung cancer at one Japanese cancer center: the need for increased cooperation between medical oncologists and surgeons.Med Oncol. 2010; 27: 932-937. Shukuya T, Yasui H, Boku N, Onozawa Y, Fukutomi A, Yamazaki K, Taku K, Kojima T, Machida N.Weekly Paclitaxel After Failure of Gemcitabine in Pancreatic Cancer Patients with Malignant Ascites: A Retrospective Study.Jpn J Clin Oncol. 2010; 40(12): 1135-8. Shukuya T, Ishiwata T, Hara M, Muraki K, Shibayama R, Koyama R, Takahashi K.Carboplatin plus weekly paclitaxel treatment in non-small-cell lung cancer patients with interstitial lung disease.Anticancer Res. 2010; 30(10): 4357-61. Takagi Y, Sato T, Morio Y, Kumasaka T, Mitani K, Miyamoto H, Iwakami S, Kodama Y, Onuma E, Seyama K, Takahashi K.A pleuro-peritoneal communication through the diaphragm affected with lymphangioleiomyomatosis.Intern Med. 2010; 49:439-445. Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H.Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.J Biol Chem. 2010; 285(6):4060-73. Takahashi K, Yoshimi K.Clinical characteristics of patients with lung cancer associated with pneumonial.Nihon Ronen Igakukai Zasshi. 2010; 47(6):550-553. Tanai C, Yamamoto N, Ohe Y, Takahashi T, Kunitoh H, Murakami H, Yamamoto N, Nakamura Y, Nokihara H, Shukuya T, Baldwin JR, Koshiji M, Tamura T.A phase I study of enzastaurin combined with pemetrexed in advanced non-small cell lung cancer.J Thorac Oncol. 2010; 5: 1068-74. Togo S, Sugiura H, Nelson A, Kobayashi T, Wang X, Kamio K, Kawasaki S, Bitterman P, Rennard SI, Liu X.Hepatic growth factor(HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells.Exp Cell Res. 2010; 316(20): 3501-3511. Wadsworth SJ, Atsuta R, McIntyre JO, Hackett TL, Singhera GK, Dorscheid DR.IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells.J Allergy Clin Immunol. 2010; 126(2): 366-374. Yanagawa M, Tomiyama N, Honda O, Kikuyama A, Sumikawa H, Inoue A, Tobino K, Koyama M, Kudo M.Multidetector CT of the lung: Image quality with garnet-based detectors.Radiology. 2010; 255(3): 944-954. Zhang S, Togo S, Minakata K, Gu T, Ohashi R, Tajima K, Murakami A, Iwakami S, Zhang J, Xie C, Takahashi K.Distinct roles of cholinergic receptors in small cell lung cancer cells.Anticancer Research. 2010; 30:97-106. 主な英文業績（2004～2006） Takahashi F, Toba M, Takahashi K, Tominaga S, Sato K, Morio Y, Nakao Y, Tajima K, Miura K, Uekusa T, Fukuchi Y.Pulmonary sarcoidosis and antiphospholipid syndrome.　Respirology. 2006 Jul;11(4):506-8. Sato T, Seyama K, Sato Y, Mori H, Souma S, Akiyoshi T, Kodama Y, Mori T, Goto S, Takahashi K, Fukuchi Y, Maruyama N, Ishigami A.Senescence Marker Protein-30 Protects Mice Lungs from Oxidative Stress, Aging and Smoking.　Am J Respir Crit Care Med. 2006 May 25 Homma N, Morio Y, Takahashi H, Yamamoto A, Suzuki T, Sato K, Muramatsu M, Fukuchi Y.Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension.Respiration. 2006;73(1):105-12.Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, Fukuchi Y.Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension.Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Fukuchi Y, Nagai A, Seyama K, Nishimura M, Hirata K, Kubo K, Ichinose M, Aizawa H, Research Group TB.Clinical efficacy and safety of transdermal tulobuterol in the treatment of stable COPD: an open-label comparison with inhaled salmeterol.Treat Respir Med. 2005;4(6):447-55. Kasagi S, Seyama K, Mori H, Souma S, Sato T, Akiyoshi T, Suganuma H, Fukuchi Y.Tomato juice prevents senescence-accelerated mouse P1 strain from developing emphysema induced by chronic exposure to tobacco smoke.Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L396-404. Gupte SA, Okada T, McMurtry IF, Oka M.Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction.Pulm Pharmacol Ther. 2006;19(4):303-9. Shiota S, Katoh M, Fujii M, Aoki S, Matsuoka R, Fukuchi Y.Predictive equations and the reliability of the impulse oscillatory system in Japanese adult subjects.Respirology. 2005 Jun;10(3):310-5. Cui R, Takahashi K, Takahashi F, Tanabe KK, Fukuchi Y.Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity.Cancer Lett. 2006 Feb 8;232(2):262-71. Ishiwata T, Takahashi K, Shimanuki Y, Ohashi R, Cui R, Takahashi F, Shimizu K, Miura K, Fukuchi Y.Serum tenascin-C as a potential predictive marker of angiogenesis in non-small cell lung cancer.Anticancer Res. 2005 Jan-Feb;25(1B):489-95. Shimanuki Y, Takahashi K, Cui R, Hori S, Takahashi F, Miyamoto H, Fukurchi Y.Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer.Lung. 2005 Jan-Feb;183(1):29-42. Takahashi F, Tsuta K, Matsuno Y, Takahashi K, Toba M, Sato K, Uekusa T, Izumi H, Nakamura K, Hirose S, Fukuchi Y.Adenocarcinoma of the thymus: mucinous subtype.Hum Pathol. 2005 Feb;36(2):219-23. Ohwada A, Sato K, Tamori Y, Yamada T.Visible male nipple shadows in chest radiographs.Respirology. 2005 Jan;10(1):111-5. Ohwada A, Kajiyama Y, Hirashima N, Miyaji A, Suzuki M.Inhalation of tobramycin in a patient with aspiration pneumonia as a result of medullary stroke.Respirology. 2004 Nov;9(4):564-7. Fukuchi Y, Nishimura M, Ichinose M, Adachi M, Nagai A, Kuriyama T, Takahashi K, Nishimura K, Ishioka S, Aizawa H, Zaher C.COPD in Japan: the Nippon COPD Epidemiology study.Respirology. 2004 Nov;9(4):458-65. リンク集 日本呼吸器学会 日本老年医学会 日本肺癌学会 日本臨床腫瘍学会 アメリカ胸部疾患学会（ATS） ヨーロッパ呼吸器学会（ERS） ページの先頭へ --> Juntendo University Facebook Twitter Instagram Youtube LINE 〒113-8421　東京都文京区本郷２丁目１番１号　 TEL： 03-3813-3111（代表） お問い合わせ サイトマップ このサイトについて プライバシーポリシー Copyright © JUNTENDO All rights reserved.